Iodometric determination of cefuroxime by the potassium hydrogenperoxomonosulphate reaction

Yu. Yu. Serdiukova, M. N. Ivashura, T. O. Oleksienko

Abstract


Simple methods for oxidimetric determination of antibiotic Cefuroxime in the substance and in the powder for solution for injection, which are based on the S-oxidation reaction by potassium hydrogenperoxomonosulphate in a weak acidic medium to S-oxide with the subsequent determination of the residual oxidising agent by the iodometric method, have been developed. A triple potassium salt of Caro's acid, 2KHSO5•KHSO4•K2SO4 was used as an oxidising agent. Quantitative oxidation of the Sulphur atom completes during the period that is less than 1 min. The mean recovery of the active ingredient in the substance of cefuroxime was 98.67%, RSD = 0.57% (δ = 0.33%). The mean recovery of the medicine “Cefuroxime”, 750 mg, is 782.8 mg, RSD = 0.97% (δ = 0.91%), which should be 680-900 mg calculated with reference to dried substance. The LOQ is C = 0.05 mg mL-1. The advantages of the method proposed are the ability of analytical determination of cefuroxime by the biologically active part of the molecule, namely alicyclic Sulphur, good precision and accuracy of the results. The validation data obtained meet the requirements of the State Pharmacopoeia of Ukraine, they indicate the possibility of its introduction in the practice of analytical laboratories analysis, application during the stepwise control process of drug manufacturing or the quality control during equipment washing.

Keywords


cefuroxime; iodometric determination; potassium hydrogenperoxomonosulphate

Full Text:

PDF

References


Фармацевтическая химия : учеб. пособие / ред. А. П. Арзамасцев. – М. : ГЭОТАР-МЕД, 2004. – 640 с.

Bernacca G., Nucci L., Pergola F. // Electroanal. - 1994. – Vol. 6, № 4. – Р. 327–332.

British Pharmacopoeia. – London : The Stationery office, 2009. – 10952 p.

Chaudari S.V., Karnik A., Adhikary A. et. al. // Ind. J. Pharm. Sci. – 2006. – Vol. 6, № 1. – Р.59-63.

El-Gindy A1., El-Walily A.F., Bedair M.F. // J. Pharm. Biomed. Anal. – 2000. – Vol. 23, № 2-3. – Р.341-352.

European Pharmacopoeia. Vol. 1-2 / European Directorate for the Quality of Medicines & Health Care. – 7th edition. – Strassbourg : – Council of Europe, 2010. – 3536 p.

Mrestani Y., Neubert R. H., Härtl A. et. al// Anal. Chim. Acta. – 1997. – Vol. 349. – Р. 207-213.

Helaleh M.I.H., Abu-Named E.S.M., Jamhour R.M.A.Q. // Acta Pol. Pharm. Drug Res. – 1998. – Vol. 55. – № 2. – Р. 93-97.

Murillo J.A., Lemus J.M., Garcia L.F. // J Pharm Biomed Analysis. – 1994. – Vol. 12, № 7. – Р.875-881.

Pospisilova B., Kubes J. // Pharmazie. – 1998. – Vol. 43, № 4. – Р. 246-248.

Rezowanur R. M., Asaduzzaman M., Ashraful S.M. // Am. J. Pharm.Tech .Res. – 2012. – Vol. 2, № 4. – Р. 351-358.

Shaha N.J., Shaha S.K., Patel V.F.et. al. // Ind. J. Pharm. Sci. – 2007. – Vol. 69, № 1. – Р. 140-142.


GOST Style Citations






DOI: https://doi.org/10.24959/88768

Abbreviated key title: Vìsn. farm.

ISSN 2415-8844 (Online), ISSN 1562-7241 (Print)