The study of the anti-exudative activity of dezapur on the model of acute pulmonary edema in rats

O. V. Sevryukov, V. A. Volkovoy, S. V. Kolisnyk, K. M. Sytnik

Abstract


The high anti-exudative action of the test compound has been found in the study of a new substance Dezapur on the model of acute toxic pulmonary edema in rats induced by the intraperitoneal introduction of 6% ammonium chloride solution in the dose of 400 mg/kg. The use of Dezapur in its effective dose of 10 mg/kg for 5 days led to decrease in pulmonary edema, the survival of animals (67%) and delayed time of death of the experimental animals in relation to the control pathology group and compared to Indomethacin, respectively. It has been found that the new substance exceeds the values of the anti-exudative activity of the reference drug Indomethacin, has a significant impact on improving the total clinical findings and outcomes. According to the preclinical studies the use of Dezapur significantly reduced the signs of intoxication, resulting in preservation of the lung mass ratio relative to the control pathology group. The substance under research can be considered promising for further study for the purpose of its introduction into medical practice as an anti-inflammatory agent.

Keywords


inflammation; lungs; 1-phenethyl-5,7-dihydro-1H-pirrolo-[2,3-d] pyrimidine-2,4,6-trion (Dezapur); indomethacin

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References


Доклінічне дослідження лікарських засобів: Метод. рекоменд. / За ред. О.В.Стефанова. – К.: Авіценна, 2001. – С. 292-306.

Кованова В.В. // Фармакол. и токсикол. – 1966. – Т. 29, №3. – С. 287-291.

Литвиненко Г.Л., Ларьяновська Ю.Б., Власов С.В. // Експеримент. і клін. медицина. – 2014. – №3(64). – С. 72-77.

Литвиненко Г.Л., Яковлєва Л.В., Власов С.В. та ін. // Клінічна фармація. – 2015. – Т. 19, №1. – С. 51-55.

Методы статистической обработки медицинских данных: Метод. рекоменд. / А.Г.Кочетов, О.В.Лянг, И.В.Жиров и др. – М.: РКНПК, 2012. – 42 с.

Резніков О.Г., Соловйов А.І., Стефанов О.В. // Вісник фармакол. і фармації. – 2006. – №7. – С. 47-61.

Ahrens J., Capelle H.H., Przemeck M. // J. Clin. Anesth. – 2008. – Vol. 20, №2. – P. 129-132.

Bramow S., Faber-Rod J., Jacobsen C. et al. // J. Mult. Scler. – 2008. – Vol. 14, №5. – P. 711-715.

Carvalho L., Carneiro R., Freire E. et al. // J. Rev. Port. Cardiol. – 2008. – Vol. 27, №2. – P. 191-199.

Dellacà R.L., Zannin E., Sancini G. et al. // J. Respir. Res. – 2008. – Vol. 12, №9. – P. 51.

Díaz N.R., Silva G.D. // J. Rev. Med. Chil. – 2008. – Vol. 136, №3. – P. 356-358.

Di Marco F., Tresoldi S., Maggiolini S. et al. // J. Anaesth. Intensive Care. – 2008. – Vol. 36, №3. – P. 351-359.

Europen convention for the protection of vertebrate animals used for experimental and other scientific purposes. – Council of Europe. Strasburg, 1986. – №123. – P. 52.

Mattu A., Martinez J.P., Kelly B.S. // Emerg. Med. Clin. North. Am. – 2005. – Vol. 23, №4. – P. 1105-1125.

Richalet J.P., Chenivesse C., Larmignat P. et al. // High. Alt. Med. Biol. – 2008. – Vol. 9, №2. – P. 179-181.


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DOI: https://doi.org/10.24959/88825

Abbreviated key title: Vìsn. farm.

ISSN 2415-8844 (Online), ISSN 1562-7241 (Print)