Substantiation of the composition and methods of quality control for “Genta+” ointment with the succinyl tannin antiresistant component
DOI:
https://doi.org/10.24959/nphj.14.2008Keywords:
ointment, gentamicin, tannin, succinyl gallotannin, multiresistant microorganisms, antibiotic resistance multiresistant microorganisms,Abstract
The results of the design and selection of compositions of antimicrobial ointments containing gentamicin as the main active substance and succinyl gallotannin as an antiresistant component. The concentration of the latter was 0.001%, had no direct antimicrobial effect, but blocked well the factors of microbial resistance and potentiated the effects of gentamicin. This composition showed antimicrobial properties against multiresistant strains of Pseudomonas aeruginosa and Staphylococcus in the experiment in vitro. According to the results of mathematical modeling the statistical hypothesis concerning the maximum mechanical stability of the ointment composition based on the carbomer with the penetration enhancer PEO-400 has been confirmed. The given composition is recommended for further development of an ointment on its basis for treating the second stage of the wound healing process complicated by multiresistant purulent infections. The low concentrations of the main active substances determine the economic prospects and expediency of the drug introduction into production.
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