Determination of toxicity of new benzilic acid derivatives

N. M. Tryschuk, I. V. Kireyev, S. V. Kolisnyk, K. M. Sytnik

Abstract


The acute toxicity of 17 new derivatives of benzilic acid in outbred mice weighing 20-26 g has been determined. Animals were divided into 68 groups of 5 mice each. Each group of animals received the aqueous solution of the substance under study once orally by gavage in the doses of 100, 250, 750, 1000 mg/kg. The total duration of follow-up of the animals after administration of the test substance was 14 days. Administration of substances under the codes of KMS-10, KMS-19, KMS-49, KMS-68, KMS-70, KMS-71, KMS-73, KMS-228, KMS-230, KMS-284 in the dose of 1000 mg/kg caused no deaths of mice. It suggests that these substances are non-toxic in the selected doses. Since the dose of 1000 mg/kg did not result in the death of animals in these groups, the conclusion can be made that LD50>1000 mg/kg. According to the classification of K.K. Sidorov the substances under study can be referred to Class IV toxicity (low-toxic compounds).


Keywords


acute toxicity; derivatives of benzilic acid; low-toxic compounds

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References


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DOI: https://doi.org/10.24959/93645

Abbreviated key title: Vìsn. farm.

ISSN 2415-8844 (Online), ISSN 1562-7241 (Print)