A comparative phytochemical and pharmacological analysis of the extracts from leaves of the ukrainian flora shrubs

Authors

  • N. A. Blyznyuk National University of Pharmacy, Ukraine
  • Yu. S. Prokopenko National University of Pharmacy, Ukraine
  • V. A. Georgiyants National University of Pharmacy, Ukraine
  • V. V. Tsyvunin National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/nphj.16.2099

Keywords:

phytochemical analysis, pharmacological analysis, Ukrainian flora, shrubs, extract

Abstract

In the Ukrainian flora such plants as Forsythia europaea Deg. et Bald, Jasminum officinale L., Berberis thunbergii DC, Weigela hybrida Jaeg., Ligustrum vulgare L., and Corylus avellana L. hold a special place among shrubs. The aim of our research was to analyse the relationship between the chemical composition and the anticonvulsant activity of the extracts from leaves of the given shrubs. The highest content of flavonoids has been determined in aqueous extracts of Forsythia europaea (2.83%) and Corylus avellana (1.95%) leaves comparing to other extracts. The highest amount of polyphenols has been determined in Corylus avellana ethanol (96%) extract (1.31%) and Jasminum officinale ethanol (50%) extract (1.30%). The dry aqueous extract of Corylus avellana leaves has shown the most pronounced anticonvulsant activity. Dry extracts of Berberis thunbergii leaves, Weigela hybrida leaves, and Ligustrum vulgare leaves have not revealed a significant anticonvulsant activity. According to the strength of the effect the dry aqueous extract of Corylus avellana can be a promising substance for creating an original herbal remedy with anticonvulsant properties.

Author Biographies

N. A. Blyznyuk, National University of Pharmacy

PhD student of Quality, standardization and certification department of Institute of Pharmacy Professionals Qualification Improvement, National University of Pharmacy

Yu. S. Prokopenko, National University of Pharmacy

Associate of professor of Quality, standardization and certification department of Institute of Pharmacy Professionals Qualification Improvement, National University of Pharmacy

V. A. Georgiyants, National University of Pharmacy

Head of Pharmaceutical chemistry department

V. V. Tsyvunin, National University of Pharmacy

PhD student of Pharmacology and drug toxicology department

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Published

2016-03-11

Issue

Section

Synthesis and Analysis of Biologically Active Substances