The justification for the choice of exipients of the prepation “Corvalol” in the form of sublingual tablets

Authors

  • I. O. Omelchenko Farmak JSC, Ukraine
  • T. G. Yarnykh National University of Pharmacy, Ukraine
  • G. I. Borschevskyi Farmak JSC, Ukraine

DOI:

https://doi.org/10.24959/nphj.16.2134

Keywords:

“Corvalol”, sublingual tablets, direct compression

Abstract

The choice of exipients for sublingual tablets “Corvalol” by the method of direct compression was based on the study of the physical properties of the tablet formulations. Three models of tablet formulations were analyzed. It is found that the optimal exipients are β-cyclodextrin, lactose monohydrate 80, potassium acesulfame, magnesium stearate. It has been demonstrated that the conclusions reached through analysis of physical parameters of the tablet formulations are confirmed by actual results of pressing.

Author Biographies

I. O. Omelchenko, Farmak JSC

Провідний фахівець Департаменту з біотехнологій ПАТ «Фармак», аспірант кафедри технології ліків НФаУ

T. G. Yarnykh, National University of Pharmacy

Ярних Тетяна Григорівна. Доктор фармацевтичних наук, професор, завідуюча кафедрою технології ліків НФаУ

 

G. I. Borschevskyi, Farmak JSC

Кандидат фармацевтичних наук, начальних лабораторії з розробки технології Департаменту з біотехнологій ПАТ «Фармак».

 

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Published

2016-09-02

Issue

No. 3(87) (2016)

Section

Technology of Medicines

License

Copyright (c) 2016 National University of Pharmacy

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