The current state and prospects of the development of soft dosage forms with Boraginaceae species
Keywords:ointment, gel, cream, Boraginaceae family, comfrey
Soft dosage forms make up a significant segment in the structure of medicines both pharmaceutical and industrial production. Herbal ointments are an integral part of this group. Species of the Boraginaceae family are the source of biologically active substances used to treat inflammatory processes of all layers of the skin, muscle tissue, tendons and joints.
Aim. To determine data on the current state of the development of soft dosage forms based on species of the Boraginaceae family and identify further prospects for studies in this area.
Materials and methods. The scientific databases, in particular Abdata Pharma-Daten-Service, BioMed Central, Scopus, scientific periodicals of Ukraine – Vernadsky National Library of Ukraine, etc., were analyzed.
Results and discussion. As a result of the data analysis of the Information Fund “State Register of Medicines of Ukraine” it has been found that only medicines with comfrey (Symphytum officinale L.) are registered in Ukraine. In the EU countries, only soft dosage forms with comfrey are registered, with the exception of Greece where there are ointments with Alkanna tinctoria (L.) Taush, and France where there are substances for the production of ointments with
Pulmonaria obscura Dumort. and Anchusa officinalis L. There are many soft homeopathic dosage forms with comfrey at the US pharmaceutical market; however, there are ointments and suppositories with Borago officinalis L. and a gel with Myosotis arvensis (L.) Hill. At the Brazilian pharmaceutical market there is the cream “Acheflan” based on Cordia verbenacea DC. The European and Asian scientists study ointments with Cordia myxa L., Cordia obliqua Willd., Heliotropium indicum L., Arnebia euchroma Rolye. (Johnst.), Onosma dichroanthum Boiss, Arnebia densiflora (Nordm.) Ledeb, Ehretia microphylla Lam., Anchusa officinalis L.
Conclusions. Homeopathic products predominate among the soft dosage forms based on Boraginaceae species. At the pharmaceutical market, along with comfrey drugs, there are medicines and active substances with Borago officinalis, Myosotis arvensis (L.) Hill, Alkanna tinctoria (L.) Taush, Pulmonaria obscura Dumort., Anchusa officinalis L. and Cordia verbenacea DC. There is an active research of the existing products with comfrey, as well as the development and study of new soft dosage forms with species of Arnebia, Heliotropium, Cordia, Onosma, Ehretia and Anchusa genus. Taking the above into account the further research for creating effective and safe drugs based on the Boraginaceae species is promising.
1. Hontova, T. M., Khvorost, O. P., Osolodchenko, T. P. (2011). Problemy ekolohichnoi ta medychnoi henetyky i klinichnoi imunolohii, 1, 307–313.
2. Gharib, A., Godarzee, M. (2016). Determination of secondary metabolites and antioxidant activity of some boraginaceae species growing in Iran. Tropical Journal of Pharmaceutical Research, 15 (11), 2459–2465. doi http://dx.doi.org/10.4314/tjpr.v15i11.15.
3. Ali, A., Hussain, F., Shahid, M. (2015). Investigation of the wound healing potential of Onosma hispidum root extract in rabbit models. Progress in Nutrition, 17 (3), 245–249.
4. The Plant List. A working list of all known plant species. Available at: http://www.theplantlist.org/1.1/browse/A/Boraginaceae/.
5. Derzhavnyi reiestr likarskykh zasobiv Ukrainy. Available at: http://www.drlz.com.ua/.
6. Offizielles gesundheitsportal der deutschen Apothekerlnnen. Available at: https://www.aponet.de/wissen/arzneimitteldatenbank/suchergebnis/Beinwell/arzneimittel.html.
7. NDC List. The complete repository of National Drug Codes Information Available at: https://ndclist.com.
8. European Medicines Agency. National registers of authorised medicines. Available at: https://www.ema.europa.eu/en/medicines/nationalregisters-authorised-medicines.
9. Perini, J., Angeli-Gamba, T., Alessandra-Perini, J. (2015). Topical application of Acheflan on rat skin injury accelerates wound healing:
a histopathological, immunohistochemical and biochemical study. BMC Complementary and Alternative Medicine, 15, 203. doi: https://doi.org/10.1186/s12906-015-0745-x.
10. Gomes, M. V. da S., da Silva, J. D., Ribeiro, A. F., Cabral, L. M., de Sousa, V. P. (2019). Development and validation of a quantification method for humulene and trans-caryophyllene in Cordia verbenacea by high performance liquid chromatography. Revista Brasileira de Farmacognosia, 29, 182–190. doi: https://doi.org/10.1016/j.bjp.2019.01.009.
11. Karami, M., Moghimipour, E., Saafi, S. (2015). Preparation And Evaluation Of Cordia Myxa Fruit Topical Cream. World Journal of Pharmaceutical Research, 4 (7), 244–253.
12. Gupta, R., Gupta, G. (2017). Formulation Development and Evaluation of Anti-inflammatory Potential of Cordia obliqua Topical Gel on Animal Model. Pharmacog J., 9 (6), 93–98. doi: https://doi.org/10.5530/pj.2017.6s.163.
13. Ayisha, S., Baskaran, K. (2016). Wound Healing Potential Of Ethanolic Leaf Extract Of Heliotropium Indicum On Excision Wound Model In Diabetic Rats. International Journal of Phytopharmacology, 7 (4), 155–158.
14. Siavash, M., Naseri, M., Rahimi, M. (2016). Arnebia euchroma ointment can reduce abdominal fat thickness and abdominal circumference of overweight women: A randomized controlled study. J Res Med Sci., 21, 63. doi: 10.4103/1735-1995.187347.
15. Aliasl J., Barikbin, B., Khoshzaban, F., Naseri, M., Sedaghat, R., Kamalinejad, M. et al. (2014). Effect of Arnebia euchroma ointment
on post-laser wound healing in rats. Journal of Cosmetic and Laser Therapy, 17 (1), 41–45. doi: 10.3109/14764172.2014.968583.
16. Nasiri, E., Hosseinimehr, S., Azadbakht, M. (2015). The Healing Effect of Arnebia Euchroma Ointment versus Silver Sulfadiazine on Burn Wounds in Rat. E. World J Plast Surg., 4 (2), 134–144. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4537605/.
17. Nasiri, E., Hosseinimehr, S. J., Hosseinzadeh, A. Z., Azadbakht, M., Akbari, J., Azadbakht, M. (2016). The effects of Arnebia euchroma ointment on second-degree burn wounds : a randomized clinical trial / E. Nasiri et al. Journal of Ethnopharmacology, 189, 107–116. doi: https://doi.org/10.1016/j.jep.2016.05.029.
18. Amirkhani, Z., Norouzian, M., Piryaei, A., Ayatollahi, S. A., Saremi, S., Dadpay, M. (2015). Histological evaluation of the effect of petroleum ether extract ointment of Onosma dichroanthum Boiss root on open skin wound healing in rat. Feyz, 19 (3), 190–196. Availabl at: http://feyz.kaums.ac.ir/article-1-2692-en.html.
19. Akkol, E., Koca, U., Peşin, I., Yilmazer, D., Toker, G., Yeşilada, E. (2009). Exploring the wound healing activity of Arnebia densiflora (Nordm.) Ledeb. by in vivo models. Journal of Ethnopharmacology, 124, 137–141. doi: 10.1016/j.jep.2009.03.019.
20. Barna, M., Kucera, A., Hladíkova, M., Kucera, M. (2012). Randomized Double-Blind Study: Wound-Healing Effects of a Symphytum Herb Extract Cream (Symphytum×uplandicum NYMAN ) in Children. Arzneimittelforschung, 62, 285–289. doi: http://dx.doi.org/10.1055/s-0032-1308981.
21. Staiger, C. (2012). Comfrey: A Clinical Overview. Phytother. Res., 26 (10), 1441–1448. doi: 10.1002/ptr.4612.
22. Kucera, M., Kálal, J., Polesná, Z. (2000). Effects of Symphytum Ointment on Muscular Symptoms and Functional Locomotor Disturbances. Advances in Therapy, 17 (4), 204–211. doi: https://doi.org/10.1007/BF02850297.
23. Mageswari, S., Karpagam, S., Reddy, G. (2015). Evaluation of wound healing activity of the plant Carmona retusa (Vahl) Masam., in mice. International Journal of integrative Sciences, Innovation and Technology, 4 (5), 1–4.
24. Svirska, S. P. (2019). Farmakohnostychne doslidzhennia roslyn rodu Volovyk. Extended abstract of candidate’s thesis. Lviv, 24.
25. Grycyk A. R., Svirska, S. P. (2017). Pryroda likuie… Roslyny rodu Volovyk: botanichna kharakterystyka, sklad ta farmakolohhichna diia. Ivano-Frankivsk, 109.
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