The thermogravimetric study of the ointment with the water-soluble proteinpolysaccharide complex of Pleurotus ostreatus

Authors

  • O. Kolpakova Institute of Chemical Technologiesof the V. Dal East Ukrainian National University
  • N. Kucherenko SE “Luhansk State Medical University” http://orcid.org/0000-0001-6462-9295
  • M. Tiukin National University of Pharmacy of the Ministry of Health of Ukraine

DOI:

https://doi.org/10.24959/nphj.21.41

Keywords:

soft dosage forms, ointment, water-soluble protein-polysaccharide complex of the oyster mushroom, thermogravimetric analysis, thermogram

Abstract

The manufacturing process for soft dosage forms is always accompanied by the action of a certain temperature, which violation can lead not only to the deterioration of technological indicators, but also significantly affect the pharmacological activity of the finished drug.
Aim. To study the water-soluble protein-polysaccharide complex (WSPPC) of Pleurotus ostreatus (oyster mushroom) and the ointment composition developed on its basis using thermogravimetry.

Materials and methods. The thermogravimetric analysis, which allowed determining the change of the mass of the test sample under the conditions of the controlled temperature rise, was chosen as the research method. Determination of thermogravimetric characteristics was performed using a Q-1500 D derivatograph of the “F. Paulik, J. Paulik, L. Erdey” system with a platinum-platinum-rhodium thermocouple when heating samples 30 to 250 °C.

Results and discussion. In the course of the thermogravimetric study it has been determined that WSPPC and the ointment composition developed on its basis have physical transformations at certain temperatures. The presence of thermal effects on the thermogram of the ointment developed coincides with the thermal effects of WSPPC; and it subjectively indicates the absence of the chemical interaction between the active pharmaceutical ingredient and the excipients of the carrier base.

Conclusions. Based on the results obtained the optimal conditions of the temperature regime for the manufacturing process have been determined. They will provide the stability of the physicochemical properties and the pharmacological effect of the finished ointment.

Author Biographies

O. Kolpakova, Institute of Chemical Technologiesof the V. Dal East Ukrainian National University

senior lecturer of the Department of Chemical and Pharmaceutical Technologies; postgraduate student of the Department of Drug Technology, Organization and Economy of Pharmacy, SE “Luhansk State Medical University”

N. Kucherenko, SE “Luhansk State Medical University”

Candidate of Pharmacy (Ph.D), associate professor, acting head of the Department of Drug Technology, Organization
and Economy of Pharmacy

M. Tiukin, National University of Pharmacy of the Ministry of Health of Ukraine

head of the Electrical Engineering Laboratory

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Published

2021-02-01

Issue

Section

Technology of Medicines