The study of epidemiology of dementia and Alzgeimer’s disease in Ukraine
Keywords:dementia; vascular dementia; Alzheimer’s disease; healthcare system; neurodegenerative pathologies
Against the background of systematic aging of the population and increase in life expectancy the problems of the spread of all forms of dementia, including Alzheimer’s disease, are becoming increasingly important.
Аim. To study epidemiology of dementia and Alzheimer’s disease in Ukraine.
Materials and methods. Data from the Center for Mental Health and Monitoring of Drugs and Alcohol of the Ministry of Health of Ukraine for 2015-2019 were studied. In the research, in addition to general theoretical methods, methods of epidemiological studies were also used.
Results and discussion. It has been found that since 2018 in Ukraine, the incidence rates of all mental disorders (4.0 %) increased, including organic lesions with symptomatic manifestations of cognitive impairment (2.0 %), all forms of dementia (6.0 %), vascular dementia and Alzheimer’s disease (9.0 % each). The structure of dementia is dominated by vascular forms of dementia (62.59 %), while Alzheimer’s disease has been characterized since 2015 by a systematic increase in the proportion (%) from 7.0 % to 12.0 %. The average prevalence of dementia in Ukraine is 99.72, and Alzheimer’s disease is 5.34 per 100 thousand population. A significant fluctuation in the prevalence of dementia and Alzheimer’s disease in different regions of the country has been proven. Thus, in the regions of the country, these indicators differed by 6 or more times. The highest prevalence rates of dementia were observed in 7 regions (Vinnytsia, Donetsk, Zaporizhia, Zhytomyr, Kharkiv, Cherkasy and Chernihiv regions) and Kyiv, and for Alzheimer’s disease – in 3 regions (Zaporizhia, Kherson, Chernihiv) and Kyiv.
Conclusions. It is necessary to introduce an effective system for recording and monitoring cases of all forms of dementia, including Alzheimer’s disease. This will form the basis for the development of models for the rational distribution of healthcare resources for the effective treatment and social rehabilitation of these groups of patients in Ukraine.
Effectiveness of educational interventions in improving detection and management of dementia in primary care: a cluster randomised controlled study / М. Downs et al. British Medical Journal. 2006. № 332. P. 692–669. DOI: https://doi.org/10.1136/bmj.332.7543.692/.
Everyday impact of cognitive interventions in mild cognitive impairment: a systematic review and meta-analysis / M. J. Chandler et al. Neuropsychology Review. 2016. Vol. 26, Iss. 3. P. 225–251. DOI: https://doi.org/10.1007/s11065-016-9330-4.
Treatment for mild cognitive impairment: a systematic review and meta-analysis / D. Fitzpatrick-Lewis et al. CMAJ Open. 2015. Vol. 3, Iss. 4. P. 419–427. DOI: https://doi.org/10.9778/cmajo.20150057.
Association between fish consumption and risk of dementia: a new study from China and a systematic literature review and meta-analysis / A. T. Bakre et al. Public Health Nutrition. 2018. Vol. 21, Iss. 10. P. 1921–1932. DOI: https://doi.org/10.1017/S136898001800037X.
Vitamin D, cognition, and dementia: a systematic review and meta-analysis / C. Balion et al. Neurology. 2012. Vol. 79, Iss. 13. P. 1397–1405. DOI: https://doi.org/10.1212/WNL.0b013e31826c197f.
Alcohol consumption, dementia and cognitive decline: an overview of systematic reviews / J. Ilomaki et al. Current Clinical Pharmacology. 2015. Vol. 10, Iss. 3. P. 204–212. DOI: https://doi.org/10.2174/157488471003150820145539.
Dementia prevention, intervention, and care / G. Livingston et al. Lancet. 2017. Vol. 390, Iss. 10113. P. 2673–2734. DOI: https://doi.org/10.1016/S0140-6736(17)31363-6.
Modifiable lifestyle factors in dementia: a systematic review of longitudinal observational cohort studies / L. Y. Di Marco et al. Journal of Alzheimer’s Disease. 2014. Vol. 42, Iss. 1. P. 119–135. DOI: https://doi.org/10.3233/JAD-132225.
Physical activity: a viable way to reduce the risks of mild cognitive impairment, Alzheimer’s disease, and vascular dementia in older adults / P. J. Gallaway et al. Brain Sciences. 2017. Vol. 7, Iss. 2. P. 22. DOI: https://doi.org/10.3390/brainsci7020022.
Global, regional, and national burden of neurological disorders during 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 / GBD 2015 Neurological Disorders Collaborator Group. Lancet Neurology. 2017. Vol. 16, Iss. 11. P. 877–897. DOI: https://doi.org/10.1016/S1474-4422(17)30299-5.
Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer’s disease / N. Geifman et al. Alzheimer’s Research & Therapy. 2017. Vol. 9, Iss. 10. P. 1. DOI: https://doi.org/10.1186/s13195-017-0237-y.
Body mass index in midlife and dementia: systematic review and meta-regression analysis of 589,649 men and women followed in longitudinal studies / E. Albanese et al. Alzheimer’s & Dementia. 2017. Vol. 8. P. 165–178. DOI: https://doi.org/10.1016/j.dadm.2017.05.007.
Coelho de Amorim J. S., Salla S., Trelha C. S. Factors associated with work ability in the elderly: systematic review. Revista Brasileira de Epidemiologia. 2014. Vol. 17, Iss. 4. P. 830–841. DOI: https://doi.org/10.1590/1809-4503201400040003.
Effect of the treatment of Type 2 diabetes mellitus on the development of cognitive impairment and dementia / A. Areosa Sastre et al. Cochrane Database of Systematic Reviews. 2017. Vol. 6, Iss. 6. CD003804. DOI: https://doi.org/10.1002/14651858.CD003804.pub2.
Designing an internet-based multidomain intervention for the prevention of cardiovascular disease and cognitive impairment in older adults: the HATICE Trial / M. Barbera et al. Journal of Alzheimer’s Disease. 2018. Vol. 62, Iss. 2. P. 649–663. DOI: https://doi.org/10.3233/JAD-170858.
Exercise training for preventing dementia, mild cognitive impairment, and clinically meaningful cognitive decline: a systematic review and meta-analysis / P. S. Barreto et al. Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 2018. Vol. 73, Iss. 11. P. 1504–1511. DOI: https://doi.org/10.1093/gerona/glx234.
Effect of timed bright light treatment for rest-activity disruption in institutionalized patients with Alzheimer’s disease / G. A. Dowling et al. International Journal of Geriatric Psychiatry. 2005. Vol. 20. P. 738–743. DOI: https://doi.org/10.1002/gps.1352.
Effect of a 24-month physical activity intervention vs health education on cognitive outcomes in sedentary older adults: the LIFE Randomized Trial / K. M. Sink et al. JAMA. 2015. Vol. 314, Iss. 8. P. 781–790. DOI: https://doi.org/10.1001/jama.2015.9617.
Potential for primary prevention of Alzheimer’s disease: an analysis of population-based data / S. Norton et al. The Lancet Neurology. 2014. Vol. 13, Iss. 8. P. 788–794. DOI: https://doi.org/10.1016/S1474-4422(14)70136-X.
Обсяг ринку препаратів для лікування хвороби Альцгеймера сягне 12,9 млрд дол. США у 2028 р. Щотижневик «Аптека». 2020. № 5. С. 42. URL: https://www.apteka.ua/article/552579.
Handbook of Medical Statistics / ed. by Ji-Qian Fang. China : Sun Yat-Sen University. 2017.
Четыркин Е. М. Статистические методы прогнозирования. Москва : Статистика, 2010. 199 с.
Copyright (c) 2021 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).