The substantiation of the technology of the cream with lespedeza extracts
DOI:
https://doi.org/10.24959/nphj.25.174Keywords:
soft dosage forms; cream with Lespedeza extracts; drug technologyAbstract
Aim. To study the dependence of the properties of a cream with lespedeza extracts on the technological parameters
of its manufacture and to develop the technology of the cream.
Materials and methods. The study object was an emulsion-based cream with bicolor lespedeza extracts. The experimental samples of the cream were emulsified using an MI-2 mixer at the speed range from 1000 to 3000 rpm in
increments of 500 rpm for 5-20 min in increments of 5 min for each sample. The quality of the manufactured samples
was assessed by appearance, thermal stability, colloidal stability, and the degree of dispersion of particles of the dispersed phase and viscosity indicators.
Results. According to the results of the experimental studies, the parameters of the technological process have
been substantiated, the manufacturing technology has been developed, and control points in the production of an
emulsion cream with lespedeza extracts for the treatment of infectious and inflammatory skin diseases have been
determined. The development of the cream technology was based on the results of the previous experimental studies
of the cream composition containing a liquid alcohol lespedeza extract and an oil lespedeza extract. Standard equipment used in the production of soft drugs was applied to produce the emulsion-based cream. The cream technology
consists of the stage of auxiliary work, several stages of the technological process (preparation of the aqueous phase,
preparation of the oil phase, preparation of the cream, preparation and homogenization of the cream), the stage of
packaging in containers, packaging in packs and group packaging for shipment to the finished product warehouse. To scale
the laboratory technology of the emulsion cream “Lespedin” into industrial production, critical production points and
conditions of the technological process have been determined, which will allow obtaining products that will meet the
requirements of the current regulatory documentation.
Conclusions. The parameters of the technological process for the production of an emulsion cream with extracts
of bicolor lespedeza have been experimentally substantiated. The technological process for manufacturing the emulsion cream with the conditional name “Lespedin” has been developed. The critical technological parameters for obtaining a soft dosage form have been determined.
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