The feasibility of developing an original anti-inflammatory drug for topical use

Abstract

Aim. To determine the feasibility of developing an original anti-inflammatory drug for topical use by analyzing the
range of the pharmaceutical market of Ukraine.
Materials and methods. A review of literature sources using the method of analysis and generalization of the data
obtained, as well as the assortment analysis of the segment of local anti-inflammatory drugs in the pharmaceutical
market of Ukraine were conducted.
Results. The classic representatives of drugs with the anti-inflammatory activity are the group of non-steroidal
anti-inflammatory drugs. They are represented by 5 dosage forms: gel, ointment, cream, transdermal patch, and spray
for external use. Most of the drugs of the group of nonsteroidal anti-inflammatory drugs are made in Ukraine, but there
are also representatives of Indian, German, Estonian production, etc. Diclofenac sodium is the most commonly used
drug among them. In addition, there are steroid drugs with the anti-inflammatory activity – topical corticosteroids. They
are available in 7 dosage forms: gel, emulsion, cream, ointment, lotion, solution and spray for external use. Most often,
the country of origin is Ukraine, but there are also products from Croatia, the USA, Germany, etc. The active pharmaceutical ingredients are usually hydrocortisone or prednisolone.
Conclusions. Anti-inflammatory drugs for topical use have an extremely wide range of products in the pharmaceutical market of Ukraine. However, because of the significant shortcomings that accompany the use of these drugs,
the development of new safe anti-inflammatory drugs for topical use is still relevant.