Development of the composition of enteric coated tablets based on ademetionine 1.4-butanedisulphonate

K. S. Burdak, T. G. Yarnykh, M. I. Borshchevska, I. B. Yanchuk

Abstract


Excipients are integral components of almost all medicines. They allow giving the necessary technological properties, which provide accurate dosing, proper strength and disintegration of tablets, to the tabletting mass. However, when developing a medicine not only the selection of the rational composition should be considered, but also the fact that excipients should not affect the properties of the active pharmaceutical ingredient and do not lead to its degradation. During the work the optimal composition of a tablet based on the substance of ademetionine 1.4-butanedisulphonate has been chosen and substantiated; compatibility of all components in the medicine has been proven.


Keywords


excipients; compatibility; ademetionine 1;4-butanedisulfonate; film coating

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References


Адеметіонін [Електронний ресурс] – Режим доступу до ресурсу: www.chemicalland21.com.

Державна фармакопея України. – Вид.1. – Харків: РІРЕГ, 2001. – 532 с.

Машковський М.Д. Лекарственные средства. В 2-х томах. – 12-е изд. − М.: Медицина. −2006. − Т.2. − 685 с.

Могилюк В. В. // Провизор. − 2009. − №6. − с. 21–24.

Плівкове покриття [Електронний ресурс] – Режим доступу до ресурсу: www.colorcon.com.

Тенденции в сфере производства таблеток и капсул // Фармацевтическая отрасль. – 2013.−№3 − С.74–75.

Фармацевтическая технология. Изготовление лекарственных препаратов: учебник / А. С. Гаврилов. – М.: ГЭОТАР-Медиа, 2010. – 624 с. : ил.

Kamble N. et al. Innovations in Tablet Coating Technology: A. Review. International Journal of Applied Biology and Pharmaceutical Technology.− 2011.− p. 214-218.

Larry L. Augsburger, Stephen W. Hoag Pharmaceutical Dosage Forms –Tablets: (Manufacture and Process Control) / L. L. Augsburger. M.: – Informa Healthcare, 2008. – 376 p.

Rowe R., Sheskey P. J. Handbook of pharmaceutical excipients. – Ed.VII. – London: APhA, 2012. – 1033 p.


GOST Style Citations






DOI: https://doi.org/10.24959/88780

Abbreviated key title: Vìsn. farm.

ISSN 2415-8844 (Online), ISSN 1562-7241 (Print)