Molecular parameters and the antimicrobial activity of functional derivatives of n-,r-amines
DOI:
https://doi.org/10.24959/nphj.16.2106Keywords:
molecular descriptors, “drug-likeness” concept, Lipinski rules, antimicrobial activityAbstract
To check for conformity of the “drug-likeness” concept in the series of functional derivatives of N-R-amines their physico-chemical parameters have been calculated using the ChemBio3D Ultra 14.0 software; they determine bioavailability according to Lipinski rules. The abovementioned derivatives are shown to be promising for further study. Using the correlation and regression analysis the quantitative “structure – antimicrobial activity” relationship has been determined among some N-R-amines, and it can be useful while searching biologically active substances in the given series.
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