6-Thio-substituted-2h-[1,2,4]triazino[2,3-c]quinazolin-2-ones with the dialkylaminoethyl moiety – a new class of antivirial agents

O. Yu. Voskoboynik, G. G. Berest, I. S. Nosulenko, L. M. Antypenko, O. V. Krivoschey, V. M. Shvets, S. I. Kovalenko

Abstract


It has been found that 6-[(b-dialkylaminoethylthio]-3-R-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones exhibit the antiviral activity against respiratory and the biodefence virus panel (EC50 3.2-36.0 mg/ml) and the influenza type A and B (EC50 1.1-18.0 mg/ml) in the visual (viral CPE) and neutral red dye uptake increasing tests. The high inhibitory activity of compound 1.5 against the strain Flu B (EC50 1.1-5.3 mg/ml) has been revealed. It has been suggested that the antiviral effect of compound 1.5 is comparable with Ribavirin. It has been shown that the planar [1,2,4]triazino[2,3-c]quinazoline system causes antiviral properties additionally determined by the b-dialkylaminoethylthiol fragment and depends on the nature of the substituent in position 3.

Keywords


6-[-dialkylaminoethylthio]-3-R-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones; biodefence viruses; respiratory viruses; antiviral activity

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References


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DOI: https://doi.org/10.24959/88801

Abbreviated key title: Vìsn. farm.

ISSN 2415-8844 (Online), ISSN 1562-7241 (Print)