The study of the effect of the critical parameters on the manufacturing process of the oil phytoextract with the hepatoprotective action

L. I. Vyshnevska, T. M. Zubchenko, O. Yu. Nkachuk

Abstract


The experimental studies conducted allow determining the critical parameters and their effect on the manufacturing process of oil extracts of the composition of the herbal raw material with the hepatoprotective action. The influence of the particle size of the raw material, concentration and the amount of ethanol on moistening of the phytocomposition and the temperature of extraction has been studied. As a result of the study the optimal parameters of extraction with the oil extractants providing efficiency of the active substances release from the herbal raw material have been determined. They are grinding of the herbal raw material by a screw shredder, an extractant for moistening is 70% ethanol in the amount of 0.6±0.1 ml per 1.0 of the raw material; the swelling time – 2.0±0.5 h; the temperature of extraction – 55±5ºC. According to the certain critical points of the manufacturing process the flowchart of manufacturing the combined oil herbal medicinal product under the conditional name “Oleosil” has been developed.

Keywords


oil extracts; critical parameters; technology; composition of the herbal raw material; hepatoprotector

Full Text:

PDF

References


Дячок В.В., Мальований М.С. // Энерготехнологии и ресурсосбережение. – 2010. – №2. – С. 72-75.

Дячок В.В., Мальований М.С. // Вопросы химии и химической техноло-гии. – 2009. – №4. – С. 177-180.

Машковський М.Д. Лекарственные средства: пособие для врачей в 2-х т. – М.: Новая волна, 2005. – 435 с.

Наймушина Л.В., Карасева А.Ю., Чесноков Н.В. // J. of Siberian Federal University Chem. – 2012. – №5. – С. 281-288.

Сорокин В.В., Вайнштейн В.А., Карнаухова И.Е., Чибиляева Т.Х. // Химико-фармац. журн. – 2008. – Т. 42, №8. – С. 23-25.

Ткачук О.Ю., Вишневська Л.І., Зубченко Т.М., Бисага Є.І. // Зб. наук. праць співроб. НМАПО ім. П.Л.Шупика. – 2015. – Т. 4, №24. – С. 311-315.

Ткачук О.Ю., Вишневська Л.І., Зубченко Т.М., Горлачова В.І. // Зб. наук. праць співроб. НМАПО ім. П.Л.Шупика. – 2015. – Т. 5, №2 – С. 234-238.

Analytical Instrument Qualification and System Validation / Ludwig Huber // Agilent Technologies Printed in Germany, January 1. 2009. – 61 p.

Design Qualification Operational Qualification HPLCE quipment Case Study Publication from www.labcompliace com Revision 1.02 May 12.2001.

Higuers-Ciapara I., Felix-Valenzuella L., Goycoolea F.M. // Grit. Rev. Food Sci. Nutr. – 2006. – Vol. 46. – P. 185-196.

Johnson T.J. // Nutr. Clin. Care. – 2002. – Vol. 5. – P. 56-65.

Rodguez-Amaya D.B., Kimura M. Harvest techn. Monograph 2. – Washington, DC and Cali: IFPRI and CIAT. Harvest Plus, 2004. – 58 p.

Solorzano Santos F., Miranda-Noveles M.G. // Current Opinion in Biotech-nol. – 2012. – Vol. 23, №2. – P. 136-141.

Tolouee van T.M., Alinezhad S., Saberi R. et al. // Intern. J. of Food Microbiol. – 2010. – Vol. 139, №3. – P. 127-133.

Unites States Pharmacopeia, Chapter “1058”, Analytical Instrument Qualification, Rockville, USA, 2008.3


GOST Style Citations






DOI: https://doi.org/10.24959/88842

Abbreviated key title: Vìsn. farm.

ISSN 2415-8844 (Online), ISSN 1562-7241 (Print)