The effect of medicines with goutweed (Aegopodium podagraria l.) On the physical endurance, cognitive functions and the level of depression in animals

O. V. Tovchiga, S. Yu. Shtrygol

Abstract


The effect of the extract (100 mg/kg and 1 g/kg) and the tincture (1 and 5 ml/kg) of the goutweed (Aegopodium podagraria L.) aerial part on the physical endurance, the level of depression and cognitive functions has been studied using the weight-loaded forced swimming test, the extrapolation escape test, and the reserpine-induced depression model. The goutweed extract in the dose of 100 mg/kg, but not in the dose of 1 g/kg, significantly increases the exhaustive swimming time (10% and 20% load) in male mice. In female mice the augmentation of exhaustive swimming time is registered with 20% load against the background of the extract in both doses. The goutweed tincture does not change the results of this test. Goutweed medicines have the ambiguous effect on the results of the extrapolation escape test: the extract and the tincture do not change the percentage of mice that succeed in completing the task, still the average time spent for the task performance is significantly decreased in these animals (but not within the whole group) against the background of the extract in the doses of 100 mg/kg and 1 g/kg. The extract in the dose of 100 mg/kg significantly reduces the number of rats capable of completing the task, the extract (1 g/kg) and the tincture (1 ml/kg) increase the time spent for performing the extrapolation escape task by rats. The extract and the tincture do not change the body temperature reduction and blepharoptosis induced by reserpine in rats. Thus, the goutweed extract is able to increase the physical endurance, exert a moderate positive effect on cognitive functions in mice (but not in rats) without any significant changes in the level of depression. The goutweed tincture worsens the results of the extrapolation escape test in the dose of 1 ml/kg, does not change them in the dose of 5 ml/kg and does not influence on the level of depression and physical endurance in both doses.

Keywords


goutweed (Aegopodium podagraria L.); extract; tincture; central nervous system; physical endurance

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DOI: https://doi.org/10.24959/88850

Abbreviated key title: Vìsn. farm.

ISSN 2415-8844 (Online), ISSN 1562-7241 (Print)