The study of the antihypoxic action of 1-phenethyl-5,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-2,4,6-trione (dezapur) on different models of hypoxia
DOI:
https://doi.org/10.24959/nphj.15.2073Keywords:
hypoxia, 1-phenethyl-5, 7-dihydro-1H-pyrrolo-[2, 3-d]pyrimidin-2, 4, 6-trione, antihypoxant drug MexidolAbstract
Extension of hypoxic states is a consequence of disorder of cerebral, coronary and peripheral circulation, and it requires further search for substances that can reduce the negative effect of hypoxia on tissues, and increase their resistance to hypoxia. The study of the antihypoxic activity of 1-phenethyl-5,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-2,4,6-trione under the conditional name of Dezapur on different models of hypoxia (hemic, hypercapnic, histotoxic and hypobaric) has been presented. The reference drug is Mexidol. Dezapur in the dose of 10 mg/kg and Mexidol in the dose of 100 mg/kg show the expressed antihypoxic activity on all models of hypoxia compared to the control group: hemic hypoxia in 2.09 and 1.82 times, hypercapnic hypoxia – in 2.35 and 2.29 times, on histotoxic hypoxia – in 2.04 and 1.9 times, hypobaric hypoxia – in 3.06 and 2.72 times, respectively.
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