The study of the chemical composition, effects on behavioural responses and the antihypoxic activity of the herbal tea and the dry extract on its basis

Ya. S. Kolisnyk, T. V. Upyr, O. M. Koshoviy, S. Yu. Shtrygol, A. M. Kovaleva

Abstract


The chemical composition and pharmacological activity of the dry extract based on the herbal tea composed of black horehound (Ballota nigra) herb, white nettle (Lamium album) herb, wormwood (Artemisiae absinthii) herb in equal amounts have been studied. As a result of the chemical study of the main groups of biologically active substances in the herbal tea and the extract on its basis the presence of phenolic compounds such as derivatives of hydroxycinnamic acid, hydroxycoumarins, flavonoids and their quantitative content have been determined. In the research objects aglycons of flavonoids (luteolin, kaempferol, quercetin, apigenin) have been idenified. 70% ethanol provides a more complete extraction of phenolic compounds from the herbal tea: the content of hydroxycinnamic acid and flavonoids is higher than in the infusion of the herbal tea, it is more than 60% and 80% respectively; the total amount of phenolic compounds in the dry extract is greater than in the infusion – more than 10% (calculated with reference to a dry residue). The results of the pharmacological research suggest the presence of the sedative effect of the dry extract from the herbal tea in the dose of 400 mg/kg. The dry extract from the herbal tea exhibits the antihypoxic activity that exceeds the activity of Piracetam, thus proving its cerebroprotective action.


Keywords


black horehound; white nettle; wormwood; herbal tea; substance; behavioural responses; antihypoxic activity

Full Text:

PDF

References


Державна фармакопея України / ДП «Науково-експертний фармакопейний центр». – 1-е вид. – Доп. 2. – Х.: ДП «Науково-експертний фармакопейний центр», 2008. – 620 с.

Доклінічні дослідження лікарських засобів: метод. рекоменд. / Н.О.Горчакова, І.С.Чекман, І.А.Зупанець та ін.; За ред. чл.-кор. АМН України О.В.Стефанова. – К.: Авіценна, 2001. – 528 с.

Kolisnyk Ya.S., Kovaleva A.M., Goryacha O.V. // Вісник фармації. – 2014. – №2. – С. 59-62.

Koshoviy O.M., Kyslichenko V.S., Velma V.V. et al. // Herba Polonica. – 2008. – Vol. 55, №1. – P. 72-77.

Kovalyova A.M., Goncharov O.V., Osmachko A.P. et al. // Х International Symposium on the Chemistry of Natural Compounds 21-23 November 2013. Tashkent-Bukhara, Uzbekistan. – 2013. – Р. 278.

Matkowski А., Tasarz P., Szypuła E. // J. of Medicinal Plants Res. – 2008. – Vol. 2(11). – P. 321-330.

Ochkur A.V. // Actual Questions of Development оf New Drugs: Abstracts оf XX International Scientific and Practical Conference of Young Scientists and Students (April 22-23, 2014). – Kh.: Publishing Office, 2014. – P. 42.

Ochkur O., Kovalyova A., Kashpur N. et al. // The Pharma Innovation J. – 2013. – Vol. 2, №9. – P. 48-50.

The top 10 causes of death [Электронный ресурс]. – Режим доступа: http://www.who.int/mediacentre/factsheets/fs310/en/index.html

The world health report 2002 – Reducing Risks, Promoting Healthy Life [Электронный ресурс]. – Режим доступа: http://www.who.int/whr/2002/en/

Vrchovská V., Spilková J., Valentão P. et al. // Food Chemistry. – 2007. – Vol. 105, I. 4. – P. 1396-1403.

Населення України (1990-2011 рр.). Статистична інформація Державної служби статистики України [Электронный ресурс]. – Режим доступа: http://www.ukrstat.gov.ua/operativ/operativ2007/ds/nas_rik/nas_u/nas_rik_u.html


GOST Style Citations






DOI: https://doi.org/10.24959/88970

Abbreviated key title: Vìsn. farm.

ISSN 2415-8844 (Online), ISSN 1562-7241 (Print)