The anti-allergic and antihistaminic properties of hydrobromide 2-[4-(41-chlorophenyl)-2- phenyliminothiazol-3-yl]-ethanol

Authors

  • O. Yu. Koshova National University of Pharmacy, Ukraine
  • H. O. Ieryomina National University of Pharmacy, Ukraine
  • L. O. Perekhoda National University of Pharmacy, Ukraine
  • Z. G. Yeryomina National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/nphj.16.2138

Keywords:

anti-allergic action, antihistaminic properties, hydrobromide 2-[4-(41- chlorophenyl)-2- phenyliminothiazol-3-yl]-ethanol

Abstract

The study of the anti-allergic action of hydrobromide 2-[4-(41-chlorophenyl)-2-phenyliminothiazol- 3-yl]-ethanol under the code of 6.6 has been conducted. On the model of anaphylactic shock in guinea pigs it has been found that in the prophylactic administration in the dose of 5 mg/kg the test compound exhibits the anti-allergic activity at the level of the reference medicine “Claritin” tablets in the dose of 1 mg/kg – 65% and 76%, respectively. In “Ophthalmic response to introduction of histamine” test the compound studied showed the efficacy on average at the level of 72%, and the reference medicine – 83%. The data obtained allow assuming that the marked antihistaminic properties play an important role in the mechanism of the anti-allergic action of compound 6.6. The research conducted prove the reasonability of further pharmacological study of hydrobromide 2-[4-(41- chlorophenyl)-2-phenyliminothiazol- 3-yl]-ethanol with the aim of creating an effective anti-allergic medicine.

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Published

2016-12-21

Issue

No. 4(88) (2016)

Section

Experimental and Clinical Pharmacology

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Copyright (c) 2016 National University of Pharmacy

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