DOI: https://doi.org/10.24959/nphj.14.1937

Microbiological studies of the ointment and rectal suppositories with liquorice root extract

O. A. Rukhmakova, T. G. Yarnykh, T. P. Osolodchenko

Abstract


While developing, preparing, packing, storing and using medicines the measures should be taken to ensure their microbiological purity taking into account the requirements of the general pharmacopoeial article “Microbiological purity of medicines”. In order to prevent microbial contamination of products it is necessary to provide them with the effective preservative action due to the introduction of antimicrobial preservatives or due to the antimicrobial preservative action of active substances and appropriate conditions of production. The aim of the work is to study the effectiveness of the preservative action of the ointment and rectal suppositories with liquorice root extract in accordance with the general pharmacopoeial article “Efficiency of antimicrobial preservatives”. The criterion for evaluating the efficiency of the preservative action of the samples investigated is reduction of the number of viable cells of microorganisms in the medicines for a certain period of time after their contamination. During the experiment it has been found that the antimicrobial preservative efficiency of the test samples correspond to the requirements of criterion “A” in accordance with the State Pharmacopoeia of Ukraine, section 5.1.3. The efficiency of the preservative action of the samples at the level of the samples with the additional content of nipagin and nipazol (in the ratio of 2:1) allows not to include additional antimicrobial preservatives in their composition.


Keywords


microbiological research; ointment; suppositories; licorice root extract

Full Text:

PDF

References


Аллергология и иммунология: национальное руководство / Под ред. Р.М.Хаитова, Н.И.Ильиной. – М.: ГЭОТАР-Медиа, 2009. – 649 с.

Державна фармакопея України / Державне підприємство «Науково-експертний фармакопейний центр». – 1 вид. – Х. : РІРЕГ, 2001. – 536 с.

Дзюба А. С. // Ремедиум. – 2013. – №9. – С. 44-48.

Про затвердження Правил виробництва (виготовлення) та контролю якості лікарських засобів в аптеках: Наказ МОЗ України №812 від 17.10.2012 р. // АПТЕКА. – 2012. – №49 (870). – С. 4-12.

Ярних Т.Г., Мельник Г.М. // Вісник фармації. – 2012. – №4 (72). – С. 12-14.

Ярних Т.Г., Мельник Г.М. // Фармац. часопис. – 2013. – №1 (25). – С. 98-102.

Antunez C., Mayorga C., Corzo J.L. et al. // Pediatric Allergy Immunol. – 2008. – Vol. 19, №3. – P. 208-209.

European Pharmacopeia. – 4th ed. – Strasbourg: Counsil of Europe, 2000. – 2570 p.

Formularium Nederlandse Apothekers. – Nederland: KNMP, 2004. – 656 s.

Halken S., Valovirta E. // Pediatric Allergy Immunol. – 2008. – Vol. 19, Suppl. 19. – P. 60-70.

Olaguibel J.M., Puebla M.J. // J. Investigations Allergol. Clin. Immunol. – 2005. – Vol. 15. – P. 9-16.

Roeder E., Berger M.Y., H. de Groot et al. // Pediatric Allergy Immunol. – 2008. – Vol. 19, №3. – P. 197-207.

United State Pharmacopeia. – XXIV ed. – Rockville: The United State Pharmacopeial, 2000. – 2569 p.

USP Pharmacists’ Pharmacopeia. – II ed. – Rockville: The United State Pharmacopeial, 2008. – 1519 p.


GOST Style Citations






Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Abbreviated key title: Vìsn. farm.

ISSN 2415-8844 (Online), ISSN 1562-7241 (Print)