Substantiation of the base composition with the purpose of creation of a soft dosage form for treating a wound process
Keywords:osmotic activity, base carrier, hydrophilic non-aqueous solvents, wound process, medicine, soft dosage form
During development of a semisolid medicinal product for the treatment of pyoinflammatory processes a special attention is paid to selection of an ointment base. The modern manufacturing of soft dosage forms for treating pyoinflammatory processes gives advantage to medicines on the hydrophilic base, which can be applied on a wound surface without disturbing perspiration. The absence of domestic medicines for treating a wound process when transferring from stage 1 to stage 2 makes particularly topical a research in developing new combined ointments for treating a wound process. One of the most important indicators of the specific action of a medicine for treating a wound process is the osmotic activity, which is involved in dehydration of a microbial cell and leads to a significant reduction of the biological activity and resistance of microbes. The osmotic activity of the samples of the ointment bases has been studied in vitro by the method of dialysis through a semi-permeable membrane in order to substantiate the optimal ointment base carrier and develop an ointment with the antibacterial and anti-inflammatory action. It has been experimentally found that the base containing the alloy of PEO-400 and PEO-1500 has the best dehydrating properties. When creating ointments for treating a wound process in transferring from stage 1 to stage 2 it should be taken into account that the most optimal are combined bases with a high effect of active medicinal substances release that intensifies their stimulating effect, as well as bases with the ability to create a moderate level of dehydration. Therefore, during the experiment in order to create a combined emulsion ointment base the following emulsifiers have been chosen – MSG and cetostearyl alcohol in the amount of 3% and 5%, respectively. Vaseline oil – 20% has been used as an oil phase (the aqueous phase is purified water – up to100 %). Based on the osmotic research conducted the composition of the emulsion base for the ointment has been substantiated; it contains: PEO-400 – 4%, PEO-1500 – 1%, MSG – 3%, cetostearyl alcohol – 5%, glycerol – 5%, vaseline oil – 20%, purified water – up to 100%.
Воловик Н.В., Ляпунов Н.А. // Фармаком. – 2001. – №2. – С. 1-10.
Гладух Є.В. // Вісник фармації. – 2002. – №4 (32). – С. 38-41.
Давтян Л.Л. // Фармац. журн. – 2003. – №3. – С. 74-77.
Допоміжні речовини та їх застосування в технології лікарських форм: довідковий посібник / Ф.Жогло, В.Возняк, В.Попович та ін. – Львів: Центр Європи, 1996. – 95 с.
Перцев И.М., Котенко А.М., Чуешов О.В., Халаева Е.Л. Фармацевтические и биологические аспекты мазей. – Х.: Изд-во НФаУ; Золотые страницы, 2003. – 288 с.
Сучасне медикаментозне лікування ран (Відомча інструкція). – К., 2002. − 35 с.
Chren M., Landefeld C.S. // JAMA. – 1994. – №22. – P. 1922-1925.
Gray J.E., McNamee P.M. // Sci. Rewiew Series. – 2000. – Vol. 1. – P. 38-49.
Maisch T. // Lasers in Medical Sci. – 2007. – Vol. 22, №2. – P. 83-91.
Young R., Lovell P. Introduction to Polymers. – London: Chapman&Hall, 1996. – 487 с.
Copyright (c) 2014 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).