The effect of the antidiabetic composition on the functional condition of the rat liver in the experimental diabetes

Authors

  • O. Yu. Koshova National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/nphj.15.2052

Keywords:

diabetes mellitus, hepatopathy, medicinal plants, antidiabetic composition

Abstract

On the model of diabetes mellitus in rats induced by the 18-days subcutaneous administration of dexamethasone in the dose of 0.125 mg/kg the hepatoprotective properties of a new antidiabetic composition based on medicinal plants have been investigated. The antidiabetic composition and the reference drug – officinal composition “Arphasetinum” were introduced intragastrically as a decoction in the dose of 18 ml/kg simultaneously with dexamethasone. According to the data obtained the antidiabetic composition exhibited a significant hepatoprotective and general metabolic effect. Under the effect of the composition studied the normalization of the basal glycemic level, recovery of the lipid balance and the bile secretory function of the liver, decrease of activity of cytolysis and inflammatory marker enzymes were observed. By its effect on the majority of the indices studied the new antidiabetic composition exceeded the reference composition “Arphasetinum”.

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Published

2015-03-16

Issue

No. 1(81) (2015)

Section

Experimental and Clinical Pharmacology

License

Copyright (c) 2015 National University of Pharmacy

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This work is licensed under a Creative Commons Attribution 4.0 International License.