The effect of substituents in the molecules of N-, R-alkyl amines on some gram-positive strains of microorganisms

Abstract

The intensive use of antibiotics in patient care institutions often without determining specificity and sensitivity to them leads to more rapid development of resistance to pathogens of nosocomial infections; that is why it is one of the urgent problems of healthcare of Ukraine. The most common gram-positive pathogens of nosocomial infections are Staphylococcus aureus, coagulase-negative staphylococci and enterococci. In order to determine dependence of the microbiological action on the nature of substituents in the molecules of N-, R-alkylamines some methyl, ethylamine, aminoalcohols, N-hydroxymethyl- and N-methyl-N-carboxymethylamines have been tested. In accordance with the WHO recommendations to assess the antibacterial activity of N-, R-alkylamines the gram-positive test strains – Staphylococcus aureus ATCC 25923 and Bacillus subtilis ATCC 6633 were used. The aliphatic amines and aminoalcohols studied show a weak or moderate activity in relation to strains of Staphylococcus aureus ATCC 25923 and Bacillus subtilis ATCC 6633. Compounds containing a carboxyl group and methyl radicals in the molecule exhibit the greatest antimicrobial activity in relation to the gram-positive strains of microorganisms under research.