The antibacterial and antifungal action of copper nanoparticles in vitro in relation to pathogenic test strains and clinical isolates of microorganisms – causative agents of infectious and inflammatory processes of different localization

Authors

  • A. V. Rudenko SI “Institute of Urology” of NAMS of Ukraine, Ukraine
  • P. V. Simonov Bogomolets National Medical University, Ukraine
  • L. S. Reznichenko F.D.Ovcharenko Institute of Biocolloidal Chemistry of NAS of Ukraine, Ukraine
  • T. G. Gruzina F.D.Ovcharenko Institute of Biocolloidal Chemistry of NAS of Ukraine, Ukraine
  • Z. R. Ulberg F.D.Ovcharenko Institute of Biocolloidal Chemistry of NAS of Ukraine, Ukraine
  • I. S. Chekman Bogomolets National Medical University, Ukraine

DOI:

https://doi.org/10.24959/nphj.15.2064

Keywords:

copper nanoparticles, test strains, clinical isolates, antibacterial, antifungal action

Abstract

The results of determination of the antibacterial and antifungal action of 20 nm copper nanoparticles obtained according to the original protocol by the method of chemical condensation in the aqueous solution in relation to the broad spectrum of pathogenic test strains such as Staphylococcus aureus MRSA ATCC 43300, Escherichia coli ATCC 2592, Pseudomonas aeruginosa ATCC 27853, S. aureus 209P, Salmonella typhimurium 144, Shigella sonnei and Candida albicans, in testing sensitivity by the method of serial dilution in agar with the doses of microorganisms of 103-105 CFU/cm3 are presented in the article. Copper nanoparticles have shown the antibacterial and antifungal action on clinical isolates of causative agents of infectious and inflammatory processes of different localization isolated from surgical patients, such as S. aureus, E. coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter aerogenes, P. aeruginosa, C. albicans, Candida non-albicans, Penicillium spp., Paecilomyces lilacinus, Aspergillus niger, and Aspergillus flavus, in testing sensitivity by the method of dosed drops with the dose for each microorganism of 107 CFU/cm3.

Author Biographies

A. V. Rudenko, SI “Institute of Urology” of NAMS of Ukraine

Head of Laboratory of microbiology, virology and mycology

P. V. Simonov, Bogomolets National Medical University

Post-graduate student of Pharmacology department

L. S. Reznichenko, F.D.Ovcharenko Institute of Biocolloidal Chemistry of NAS of Ukraine

С.н.с. отдела коллоидной технологии природных систем

T. G. Gruzina, F.D.Ovcharenko Institute of Biocolloidal Chemistry of NAS of Ukraine

С.н.с. отдела коллоидной технологии природных систем

Z. R. Ulberg, F.D.Ovcharenko Institute of Biocolloidal Chemistry of NAS of Ukraine

Head of Institute

I. S. Chekman, Bogomolets National Medical University

Head of Pharmacology Departament

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Published

2015-12-02

Issue

No. 4(84) (2015)

Section

Experimental and Clinical Pharmacology

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