Development of the composition and technology of a caries preventive gel

Abstract

Prevention of dental caries involves remineralization of the tooth surfaces with calcium and phosphorus medicines, but the use of fluorine- containing remedies in the form of a cream, gel and varnish is more effective. The aim of our work was to substantiate the composition and technology of a gel with cetylpyridinium hexafluorosilicate having the caries preventive action. A gelling agent – hydroxyethyl cellulose that provides stability and the essential structural and mechanical properties of the gel has been selected experimentally. Microscopic studies have substantiated introduction of the solubilizer PEG-40 hydrogenated castor oil in the concentration of 0.5% that promotes dissolution of the peppermint essential oil with preserving the gel transparency. The use of 10% sorbitol has been substantiated to provide the moderate osmotic properties and to prevent the gel drying. Microbiological studies have shown the necessity of using sodium benzoate as a preservative in the concentration of 0.3%. The temperature regimen of cetylpyridinium hexafluorosilicate introduction in the composition of the gel base has been substantiated by thermogravimetric studies. The technology of gel has been developed.