The quantitative relationships of the partition coefficients calculated in the series of n-r-amine functional derivatives

Authors

  • M. Yu. Golik National University of Pharmacy, Ukraine
  • O. S. Kryskiv National University of Pharmacy, Ukraine
  • A. M. Komissarenko National University of Pharmacy, Ukraine
  • O. V. Kolisnyk National University of Pharmacy, Ukraine
  • K. I. Dudka National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/nphj.16.2087

Keywords:

partition coefficient, calculation methods, correlation, N-R-amine derivatives

Abstract

Using on-line services and the ChemBioOffice2014 software package the values of the partition coefficients of some N-R-amine derivatives have been calculated. To identify the quantitative relationships and select the optimal algorithm of calculations the correlation and regression analysis of the values obtained has been conducted. Statistically significant values of correlation for the partition coefficients calculated have been determined. It has been shown that it is advisable to use the value AlogPs for further application.

Author Biographies

M. Yu. Golik, National University of Pharmacy

Department of Analytical Chemistry

O. S. Kryskiv, National University of Pharmacy

Department of Inorganic Chemistry

A. M. Komissarenko, National University of Pharmacy

Department of Chemistry of Natural Compound

O. V. Kolisnyk, National University of Pharmacy

Department of Pharmaceutical Chemistry

K. I. Dudka, National University of Pharmacy

Student

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Published

2016-03-11

Issue

No. 1(85) (2016)

Section

Synthesis and Analysis of Biologically Active Substances

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Copyright (c) 2016 National University of Pharmacy

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