The study of the antihypoxic activity of new derivatives of benzilic acid

Authors

  • I. V. Kireev National University of Pharmacy, Ukraine
  • S. V. Kolisnyk National University of Pharmacy, Ukraine
  • N. M. Tryshchuk National University of Pharmacy, Ukraine
  • K. M. Sytnik National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/nphj.16.2089

Keywords:

antihypoxic activity, derivatives of benzilic acid

Abstract

On the model of acute normobaric hypoxic hypoxia with hypercapnia the antihypoxic action of new derivatives of benzilic acid, namely – N-heterylamides of benzilic acid and products of their intramolecular cyclodehydration – thienolactams with five-, six- and seven membered cycles, respectively. Amides have also been studied on the basis of five-membered lactam – derivatives of thieno[3,4-b]pyrrol-6-carboxylic acid. According to the result of our studies the following regularities have been found. The cyclization products of benzilic acid amides significantly exceed the antihypoxic activity of the parent compounds, and it indicates the prospects of conducting the studies among the products of heterocyclization of N- heterylamides of benzilic acid. It should also be noted that modification of the ester group in position 6 of 2-oxo-3,3-diphenyl-2,3-dihydro-1Н-thieno[3,4-b]pyrrole-6-carboxylic acid appeared to be appropriate. Amides based on this compound (KMS-68, KMS-69, KMS-71) during the experiment showed the maximum life span of the animals under research.

Author Biographies

I. V. Kireev, National University of Pharmacy

Head of Pharmacotherapy Departament

S. V. Kolisnyk, National University of Pharmacy

Профессор кафедры аналитической химии

N. M. Tryshchuk, National University of Pharmacy

Доцент кафедры фармакотерапии

K. M. Sytnik, National University of Pharmacy

Доцент кафедры органической химии

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Published

2016-06-13

Issue

No. 2(86) (2016)

Section

Experimental and Clinical Pharmacology

License

Copyright (c) 2016 National University of Pharmacy

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