6-Thio-substituted-2h-[1,2,4]triazino[2,3-c]quinazolin-2-ones with the dialkylaminoethyl moiety – a new class of antivirial agents

Authors

  • O. Yu. Voskoboynik Zaporizhzhia State Medical University, Ukraine
  • G. G. Berest Zaporizhzhia State Medical University, Ukraine
  • I. S. Nosulenko Zaporizhzhia State Medical University, Ukraine
  • L. M. Antypenko Zaporizhzhia State Medical University, Ukraine
  • O. V. Krivoschey Zaporizhzhia State Medical University, Ukraine
  • V. M. Shvets Zaporizhzhia State Medical University, Ukraine
  • S. I. Kovalenko Zaporizhzhia State Medical University, Ukraine

DOI:

https://doi.org/10.24959/nphj.16.2093

Keywords:

6-[-dialkylaminoethylthio]-3-R-2H-[1, 2, 4]triazino[2, 3-c]quinazolin-2-ones, biodefence viruses, respiratory viruses, antiviral activity

Abstract

It has been found that 6-[(b-dialkylaminoethylthio]-3-R-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones exhibit the antiviral activity against respiratory and the biodefence virus panel (EC50 3.2-36.0 mg/ml) and the influenza type A and B (EC50 1.1-18.0 mg/ml) in the visual (viral CPE) and neutral red dye uptake increasing tests. The high inhibitory activity of compound 1.5 against the strain Flu B (EC50 1.1-5.3 mg/ml) has been revealed. It has been suggested that the antiviral effect of compound 1.5 is comparable with Ribavirin. It has been shown that the planar [1,2,4]triazino[2,3-c]quinazoline system causes antiviral properties additionally determined by the b-dialkylaminoethylthiol fragment and depends on the nature of the substituent in position 3.

Author Biographies

O. Yu. Voskoboynik, Zaporizhzhia State Medical University

Organic and bioorganic chemistry department

G. G. Berest, Zaporizhzhia State Medical University

Pharmacognosy, pharmaceutical chemistry and pharmaceutical technology Department

I. S. Nosulenko, Zaporizhzhia State Medical University

Pharmacology, pharmacognosy and botany department

L. M. Antypenko, Zaporizhzhia State Medical University

Organic and bioorganic chemistry department

O. V. Krivoschey, Zaporizhzhia State Medical University

Pharmaceutical chemistry Department

V. M. Shvets, Zaporizhzhia State Medical University

Biochemistry and laboratory diagnostic department

S. I. Kovalenko, Zaporizhzhia State Medical University

Organic and bioorganic chemistry department

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Published

2016-06-13

Issue

No. 2(86) (2016)

Section

Experimental and Clinical Pharmacology

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