Development of the composition of the gel base for treating telogen effluvium
DOI:
https://doi.org/10.24959/nphj.16.2097Keywords:
telogen effluvium, nettle juice, gels, bases, preservatives, hydrophilic non-aqueous solventsAbstract
The article presents the study results of developing the optimal composition for the base of the maskgel for treating telogen effluvium. The effect of the preservative potassium sorbate in different concentrations (from 0.1% to 0.3%) on the pH and structural-mechanical properties of gels has shown that its 0.2% content provides pH 5 to the base, and it corresponds to the skin surface acid-alkaline physiological range; the structural viscosity and thixotropy, the mechanical stability (MS) value (1.04) and the high Kd rate (63.48) corresponding to the optimal technological and consumer properties of the gel base have been determined. The results of the biopharmaceutical and rheological studies have confirmed that the base with 5% glycerin has the best ability to retain moisture in the composition, possesses the insignificant osmotic effect, and is characterized with proper viscosity compared to other hydrophilic non-aqueous solvents (HNS) such as propylene glycol, the HNS mixture in the ratio of 1:1. Therefore, the gel base of the following composition: sodium alginate – 1.0 g; carbopol (Ultrez 10) – 1.0 g; glycerin – 5.0; potassium sorbate – 0.2; purified water – up to 100.0 g has the optimal properties.
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