The study of the amino acid composition of the extracts obtained from cherry leaves and shoots, leaves of apricot and peach
Extracts were obtained from raw materials of cultivated plants from family Rosaceae and pharmacological screening was carried out. It was found that extract of cherry shoots showed diuretic activity higher than the comparator hypothiazide at a dose of 100 mg / kg, extracts from cherry and apricot leaves had significant anti-inflammatory activity in a dose of 25 mg / kg, extract from peach leaves showed immunotropic activity in low concentration of 0.4 mg / ml detected in vitro These extracts are promising for further study and creation of new medicines on their basis. Composition and content of free amino acids in the dry extracts obtained from the leaves and shoots of cherry, leaves of apricot and soft extract from peach leaves were determined by HPLC. The presence of 21 amino acids of which eight are essential - threonine, valine, isoleucine, leucine, phenylalanine, histidine, lysine and arginine, was established. Proline, asparagine, γ-aminobutyric and glutamic acids, arginine and alanine prevailed. All extracts were free from cystine and methionine and only extracts from the leaves of cherry and peach contained cysteine in small amount. The dry extract of cherry shoots had the largest amount of amino acids - 3154.2 mg / L, the lowest - the extract from apricot leaves - 605.9 mg / L.
Voronina L.М., Kravchenko G.B., Zagaiko А.L. et al. // News of Pharmacy. – 2010. - №1. – P. 66-68.
Kravchenko A.B., Fayzullin A.V., Puzak О.А. et al. // Ukrainian Journal of Clinical and Laboratory Medicine. – 2009. – Vol. 4, №4. – P. 44-46.
Popovich V. P., Upyr L. V., Kyslychenko V. S. // Actual problems of theoretical, clinical, preventive medicine, dentistry and pharmacy: materials of 72 th International Scientific Conference of students and young scientists. – Donetsk, 2010. – P. 280-281.
Puzak О.А., Upyr L. V., Kyslychenko V. S.et al., // Pharmacy of Kazakhstan: integration of science, education and industry: Materials of the International scientific-practical conference. –Shymkent, Kazakhstan. – 2009. - Vol. 1. - P. 267-270.
Shtroblіa А.L., Fira L.S., Kyslychenko V. S.et al., // Achievements of Clinical and Experimental Medicine. – 2011. – № 1. – P.110-113.
Egebjerg J., Schousboe A., Krogsgaard-Larsen P. Glutamate and GABA Receptors and transporters; Structure, Function and Pharmacology. London: Taylor and Francis, 2002. – P. 287-304.
Jámbor А., Molnár-Perl I. // Journal of Chromatography A. – 2009. – Vol. 1216. – Р. 6218–6223.
Jámbor А., Molnár-Perl I. // Journal of Chromatography A. – 2009. – Vol. 1216. – Р. 3064–3077.
Kyslychenko V.S., Lenchyk L. V., Navruzova G.F. The 15-th International Congress of the International Society for Ethno-Pharmacology (05-08 May, 2015, Petra-Jordan). – Petra: 2015. – P. 114-115.
Koga Y., Akita Y, Junko N, et al. // Neurology. – 2006. – Vol. 66 № 11. – Р. 1766-9.
GOST Style Citations
This work is licensed under a Creative Commons Attribution 4.0 International License.
Abbreviated key title: Vìsn. farm.
ISSN 2415-8844 (Online), ISSN 1562-7241 (Print)