“Greening” of Amizone synthesis when manufacturing

Authors

  • V. A. Georgiyants National University of Pharmacy, Ukraine
  • V. M. Kushniruk National University of Pharmacy, Ukraine
  • P. O. Bezugly National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/nphj.16.2105

Keywords:

Amizone, manufacturing synthesis, “green chemistry”

Abstract

The principles of “green chemistry” have been introduced into the procedure of manufacturing synthesis of Amizone. All starting raw materials as solvents have been assessed in accordance with their human toxicity, danger in production, as well as the possible impact on the environment and cost. According to the results of the analysis isonicotinic acid has been chosen as a starting substance for the synthesis at the first step, and the synthetic procedure without solvents has been proposed. The replacement of acetone with isopropanol has been proposed for the alkylation step according to the data concerning toxicity and manufacturing safety. Aqueous ethanol has been chosen as a solvent for recrystallisation. To reduce the impact on the environment the process of conversion of the benzylamine excess into less toxic and flammable hydrochloride has been recommended.

References

  1. Георгиянц В.А., Кушнирук В.Н., Гарная Н.В. // Вестник Южно-Казахстанской фармацевтической академии. – 2014. – Т. 2, №3. – С. 27-30.
  2. Георгиянц В.А., Кушнирук В.Н., Гарная Н.В. // Запорожский мед. журн. – 2014. – №4(85). – С. 86-89.
  3. Кушнірук В.М., Георгіянц В.А., Гарна Н.В. // Фармац. часопис. – 2013. – №4. – С. 12-15.
  4. Anastas P.T., Warner J.C. Green Chemistry: Theory and Practice, Oxford University Press. – New York, 1998. – P. 30.
  5. Bing-Feng Sun // Tetrahedron Lett. – 2015. – Vol. 56, №17. – P. 2133-2140.
  6. Globally Harmonized System of Classification and Labelling of Chemicals (GHS), United Nations Economic Commission for Europe. – 2007. – Р. 839-924.
  7. Haleema R.M., Salemb M.Y., Fatahallaha F.A., Abdelfattah L.E. // Saudi Pharmac. J. – 2015. – Vol. 23, №5. – P. 463-469.
  8. Jolliffe H.G., Gerogiorgis D.I. // Chemical Engineering Res. and Design. – 2015. – Vol. 97, №5. – P. 175-191.
  9. Rastogi T., Leder C., Kümmerer K. // Chemosphere. – 2014. – Vol. 111, №9. – P. 493-499.
  10. Ur Rehmana M.S., Rashida N., Ashfaqb M. et al. // Chemosphere. – 2015. – Vol. 138, №11. – P. 1045-1055.
  11. Velagaletia R., Burns P. // Particulate Sci. and Technol. – 2007. – Vol. 25, №2. – Р. 117-127.

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Published

2016-03-11

Issue

No. 1(85) (2016)

Section

Technology of Medicines

License

Copyright (c) 2016 National University of Pharmacy

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.