Molecular parameters and the antimicrobial activity of functional derivatives of n-,r-amines

Authors

  • M. Yu. Golik National University of Pharmacy, Ukraine
  • O. S. Kryskiv National University of Pharmacy, Ukraine
  • K. I. Dudka National University of Pharmacy, Ukraine
  • O. V. Kolisnyk National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/nphj.16.2106

Keywords:

molecular descriptors, “drug-likeness” concept, Lipinski rules, antimicrobial activity

Abstract

To check for conformity of the “drug-likeness” concept in the series of functional derivatives of N-R-amines their physico-chemical parameters have been calculated using the ChemBio3D Ultra 14.0 software; they determine bioavailability according to Lipinski rules. The abovementioned derivatives are shown to be promising for further study. Using the correlation and regression analysis the quantitative “structure – antimicrobial activity” relationship has been determined among some N-R-amines, and it can be useful while searching biologically active substances in the given series.

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Published

2016-06-13

Issue

No. 2(86) (2016)

Section

Experimental and Clinical Pharmacology

License

Copyright (c) 2016 National University of Pharmacy

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This work is licensed under a Creative Commons Attribution 4.0 International License.