Molecular parameters and the antimicrobial activity of functional derivatives of n-,r-amines

Authors

  • M. Yu. Golik National University of Pharmacy, Ukraine
  • O. S. Kryskiv National University of Pharmacy, Ukraine
  • K. I. Dudka National University of Pharmacy, Ukraine
  • O. V. Kolisnyk National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/nphj.16.2106

Keywords:

molecular descriptors, “drug-likeness” concept, Lipinski rules, antimicrobial activity

Abstract

To check for conformity of the “drug-likeness” concept in the series of functional derivatives of N-R-amines their physico-chemical parameters have been calculated using the ChemBio3D Ultra 14.0 software; they determine bioavailability according to Lipinski rules. The abovementioned derivatives are shown to be promising for further study. Using the correlation and regression analysis the quantitative “structure – antimicrobial activity” relationship has been determined among some N-R-amines, and it can be useful while searching biologically active substances in the given series.

Author Biographies

M. Yu. Golik, National University of Pharmacy

Доцент кафедры аналитической химии

O. S. Kryskiv, National University of Pharmacy

Доцент кафедри неорганічної хімії

K. I. Dudka, National University of Pharmacy

тудент

O. V. Kolisnyk, National University of Pharmacy

Доцент кафедры фармацевтической химии

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Published

2016-06-13

Issue

Section

Experimental and Clinical Pharmacology