The place of meloxicam in the series of modern non-steroidal anti-inflammatory drugs

Authors

  • G. V. Zaychenko National University of Pharmacy, Ukraine
  • O. M. Liapunov State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine, Ukraine
  • O. P. Bezugla State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine, Ukraine

DOI:

https://doi.org/10.24959/nphj.16.2118

Keywords:

non-steroidal anti-inflammatory drugs, meloxicam, rheumatologic diseases

Abstract

The article describes the pharmacological characteristics of the first selective COX-2 inhibitor – meloxicam, aspects of its mechanism of action, peculiarities of pharmacodynamics and indications, as well as the advantages of the drug compared to the classic and highly selective NSAIDs in terms of safety. The efficiency and safety of meloxicam have been confirmed in 230 clinical trials, in which more than 30 thousands patients took part. In most of them it has been proven that meloxicam is as effective as classic NSAIDs, and moreover, it has a high safety profile, particularly with regard to the GI tract. By severity of the anti-inflammatory and analgesic effect meloxicam is not inferior to conventional NSAIDs, and compares favourably with them by good tolerability with regard to the gastrointestinal and cardiovascular safety, and it can be recommended as a drug of the first choice for the treatment of inflammatory and degenerative arthropathies.

Author Biographies

G. V. Zaychenko, National University of Pharmacy

Head of the Clinical Pharmacology Department

O. M. Liapunov, State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine

Инженер 1 категории отдела оптически активных органических соединений

O. P. Bezugla, State Scientific Institution “Institute for Single Crystals” of National Academy of Sciences of Ukraine

Старший научный сотрудник отдела оптически активных органических соединений

References

Алексеев В.В., Алексеев А.В. // Consilium medicum. – 2007. – № 2. – С. 28–32.

Безуглая Е.П., Ляпунов А.Н., Либина В.В. и др. // Клінічна фармація. – 2015. – Т. 19, №3. – С. 48-55.

Дроговоз С.М., Штрыголь С.Ю., Щекина Е.Г. Фармакология в помощь студенту, провизору и врачу: Учебник-справочник. – Х.: Титул, 2013. – 900 с.

Каратеев А.Е. // Ревматология. Травматология. Ортопедия. − 2011. − № 1. − С. 28-36.

Каратеев А.Е., Успенский Ю.П., Пахомова И.Ю. и др. // Науч.-практ. ревматол. – 2012. - № 52 (3). – С. 101-116.

Клиническая фармакология и фармакотерапия / Под ред. В.Г. Кукеса, А.К. Стародубцева. – М.: ГЭОТАР-Медиа, 2012. – 832 с.

Компендиум 2014 – лекарственные препараты / Под ред. В.Н. Коваленко – К.: МОРИОН, 2014. – 2448 с.

Кукушкин М.Л., Табеева Г.Р., Подчуфарова Е.В. Болевой синдром: патогенез, клиника, лечение. Клинические рекомендации. – М.: ИМА-пресс, 2011. − 79 с.

Курята А.В., Лысунец Т.К., Зайченко А.В., Черкасова А.В. Боль и проблема безопасности НПВС: монография. − Днепропетровск : Герда, 2014. − 84 с.

Максимов М.Л. // Русский мед. журнал. − 2013. − Т. 21, № 34. − С. 1734–1736.

Осипова Н.А., Абузарова Г.Р., Петрова В.В. Принципы применения анальгетических средств при острой и хронической боли. Клинические рекомендации. – М.: ФГБУ «МНИОИ им. П.А.Герцена Минздравсоцразвития России», 2010. − 67 с.

Пасечников В.Д. // Consilium medicum. − 2013. − № 15 (9). − С. 76-80.

Штрыголь С.Ю. // Провизор. – 2005. – №2. – С. 10-12.

Ahmed M., Khanna D., Furst D.E. // Expert Opin Drug Metab Toxicol. – 2005. – № 1(4). – P. 739–751.

Altman R., Hochberg M., Gibofsky A. et al. // Osteoarthritisand Cartilage. – 2015. – Vol. 23, Suppl. 2. – P. A324-A325.

Altman R., Luciardi H.L., Muntaner J. et al. // Circulation. – 2002. – Vol. 106. – P. 191-195.

Annigeri R. G., Jadhav M., Juturu T. // Indian journal of pain. – 2015. – Vol. 29, Issue 2. – P. 82-85.

Bavbek S., Dursun A.B., Dursun E. // Int Arch Allergy Immunol. – 2006. – № 142(1). – P. 64–69.

Bosch H.C., Sigmund R., Hettich M. // Curr Med Res Opin. – 1997. – № 14. – P. 29-38.

Cai W. X., Ma L., Zheng L. W. et al. // Clinical Oral Implants Research. 2015. – Issue 4. – P. 478-483.

Camu F., Shi L., Vanlesberghe C. // Drug. – 2003. – Vol. 63, Suppl. 1. – P. 1–7.

Charlton A. N. , Benito J., Simpson W. et al. // Journal of Feline Medicine and Surgery. – 2013. – № 15(8). – P.678-690.

Chen Y.F., Jobanputra P., Barton P. et al. // Health Technology Assessment. – 2008. – Vol. 12 (Suppl. 11). – Р. 1-278.

Chou R., McDonagh M.S., Nakamoto E. et al. // Rockville (MD): Agency for Healthcare Research and Quality (US). – 2011. – Vol. 38. – Р. 1-148.

Coetzee J. F., Mosher R. A., Griffith G. R. et al. // Journal of Veterinary Pharmacology and Therapeutics. – 2015. – Vol. 38, Issue 6. – P. 556–562.

Colberg K., Hettich M., Sigmund R. et al. // Curr Med Res Opin. – 1996. – № 13 (7). – P. 363–377.

Combe B., Velicitat P., Garzon N. et al. // Inflamm Res. – 2001. – Vol. 50 (Suppl. 1). – P. S10-16.

Davies N.M., Skjodt N.M. // Clin Pharmacokinet . – 1999. – Vol. 36. – P. 115-126.

De Menezes S.A.F., Cury P.R. // International Journal of Oral and Maxillofacial Surgery. – 2010. – № 39. – P. 580-584.

Degner F., Leonard J., Sigmund R. et al. // Conference on Progress in the Field of Selective COX-2 Inhibitors; Nice 2001 Sep 30-Oct 2.

Degner F., Sigmund R., Zeidler H. // Clin Ther. – 2000. – Vol. 22. – P. 400-410.

Del Tacca M., Colucci R., Fornai M. et al. // Clin Drug Ivest. – 2002. – № 22(12). – P. 799–818.

Dequeker J., Hawkey C., Kahan A. et al. // Br J Rheumatol. – 1998. – Vol. 37. – P. 946-951.

Distel M., Mueller C., Bluhmki E. et al. // Br J Rheumatol. – 1996. – № 35 (Suppl. 1). – P. 68–77.

Dreiser R.L., Le Parc J.M., Velicitat P. et al. // Inflamm Res. – 2001. – Vol. 50 (Suppl. 1). – P. S17-23.

El-Rwegi W.M., Elgerwi A.A., El-Mahmoudy A.M. et al. // Int J Basic Clin Pharmacol. – 2015. – № 4(5). – P. 924-930.

Ghodsi S. M., Mohebbi N., Naderi S. et al // Iran J Pharm Res. – 2015. – № 14(1). – P. 125–130.

Goei The H.S., Lund B., Distel L.M. et al. // Osteoarthr Cartil. – 1997. – № 5. – P. 283-288.

Gomes F. I. F., Aragão M. G. B., Pinto V. de P. T., Gondim D. V. et al // Journal of Oral Implantology. – 2015. – № 41. – P. 219-230.

Gonzalez Maza C., Moscoso López L., Ramírez Elizalde G. et al // Acta Ortop Mex. − 2010. – Vol. 24(2). – P. 88-94.

Hassan A. F., Helmy S. A., Donia A. // J. Braz. Chem. Soc. – 2015. – Vol.26, № 7. – P. 126-138.

Hawkey C., Kahan A., Steinbrück K. et al. // Br J Rheumatol. – 1998. – Vol. 37. – P. 937-945.

Hawkey C., Kahan A., Steinbrück K. et al. // Rheumatology (Oxford). – 1999. – № 38 (8). – P. 793-845.

Hawkey C.J. // J. Cardiovasc. Pharmacol. − 2006. − Vol. 47 (Suppl. 1). − Р. 72–75.

Huskisson E.C., Ghozlan R., Kurthen R. et al. // Br J Rheumatol. – 1996. – Vol. 35 (Suppl. 1). – P. 29-34.

IASP Committee on Taxonomy, 2012 (Международная ассоциация по изучению боли IASP) http://www.iasp-pain.org.

Lapicque F., Vergne P., Jouzeau J-I. et al. // Clin Pharmacokinet. – 2000. – № 39. – P. 369-382.

Layton D., Hughes K., Harris S. et al. // Rheumatology. – 2003. – № 42. – P. 1–11.

Lee H.J., Kim Y.H., Kim S.H. et al // Clinical Therapeutics. – 2015. – Vol. 37, Issue 8. – P. e60-e61.

Lemmel E.M., Bolten W., Burgos-Vargas R. et al. // J Rheumatol. – 1997. – Vol. 24. – P. 282-290.

Lipscomb G.R., Wallis N., Armstrong G. et al. // Br J Clin Pharmacol. – 1998. – Vol. 46. – P. 133-137.

Lund B., Distel M., Bluhmki E. // Scand J Rheumatol. – 1998. – Vol. 27. – P. 32-37.

Maiden L., Thjodleifsson B., Seigal A. et al. // Clin. Gastroenterol. Hepatol. − 2007. − Vol. 5. − P. 1040–1045.

Martin R.M., Biswas P., Mann R.D. // Br J Clin Pharmacol. – 2000. – Vol. 50. – P. 35-42.

Matsumoto T., Kudo T., Esaki M. et al. // Scand. J. Gastroenterol. − 2008. − Vol. 43. − P. 490–496.

Pablos A.B., Ramalho S.A., König Jr. B. et al // Journal of Periodontology. – 2008. – Vol. 79, № 2. – P. 300-306.

Povoroznyuk V.V., Bystrytska M.A., Orlyk T.V. // Abstract Book (APLAR, Japan, September 23–27, 2008). − 2008. − P. 89.

Reginster J.Y., Distel M., Bluhmki E. // Br J Rheumatol. – 1996. – Vol. 35 (Suppl. 1). – P. 17-21.

Rømsing J., Mysager S., Vilmann P. et al. // Can J Anaesth. – 2001. – Vol. 48. – P. 978-984.

Santos A. R. S., Vedana E. M. A., De Freitas G. A. G. / Inflamm. res. – 1998. – Vol. 47. – P. 302–307.

Schoenfeld P. // Am J Med. – 1999. – № 107. – P. 48–54.

Schoenfeld P. // Am J Med. – 2003. – Vol. 43 (Suppl 6A). – P. 22-30S.

Singh G., Triadafilopoulos G. // European Congress of Rheumatology, Prague 2001 Jun 13-16.

Speranza C. , Schmid V., Giraudel J. M. et al. // BMC Veterinary Research. – 2015. – № 11. – P. 79.

Tavares I.A. // Aliment Pharmacol Ther. - 2000. – № 14. – P. 795-799.

Thompson J.P., Sharpe P., Kiani S. et al. // Br J Anaesth. – 2000. – Vol. 84. – P. 151-154.

Tsubouchi Y., Sano H., Yamada R. et al. // Eur J Pharmacol. – 2000. – Vol. 395. – P. 255-163.

Valat J.P., Accardo S., Reginster J.Y. // Inflamm Res. – 2001. – № 50 (Suppl. 1). – Р. S30–34.

Van Hecken A., Schwartz J.I., Depré M. et al. // J Clin Pharmacol. – 2000. – Vol. 40. – P. 1109-1120.

Wojtulewski J.A., Schattenkirchner M., Barcelo P. // Br J Rheumatol. – 1996. – № 35 (Suppl. 1). – Р. 22–28.

Yocum D., Fleischmann R., Dalgin P. et al. // Arch Intern Med. – 2000. – № 160(19). – P. 2947-2954.

Zeidler H., Kaltwasser J.P., Leonard J.P. et al // J Clin Rheumatol. – 2002. – № 8 (6). – P. 305–315.

Downloads

Published

2016-06-13

Issue

No. 2(86) (2016)

Section

Experimental and Clinical Pharmacology

License

Copyright (c) 2016 National University of Pharmacy

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).