The technological aspects of creating a solid dosage form based on metformin and benfotiamine
DOI:
https://doi.org/10.24959/nphj.16.2120Keywords:
metformin, benfotiamine, antidiabetic drug in capsulesAbstract
Today one of the major problems for the healthcare system of most countries in the world is to optimize pharmacotherapy of diabetes mellitus (DM), which from the category of endemic diseases has turned into a global epidemy in recent decades. In Ukraine there are no drugs that would contain metformin and benfotiamine in their composition, and their combination has not been registered. Creation of a combined drug for the treatment of diabetes mellitus type 2 based on metformin and benfotiamine is promising and will allow not only to control diabetic hyperglycemia qualitatively, but also to prevent development of diabetic polyneuropathy, as well as to reduce side effects of drugs in the combination due to their lower dose. The crystallographic, physicochemical and technological properties of the substances of metformin hydrochloride and benfotiamine, as well as their mixtures have been studied. As a result of the crystallographic, physicochemical and technological studies the composition of the original combined drug in the form of capsules based on metformin and benfotiamine has been developed; it contains metformin – 0.400 g, benfotiamine – 0.020 g, excipients – 0.080 g. The composition of the capsules with metformin and benfotiamine developed has good technological characteristics allowing to choose the direct filling of capsules.
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Suzuki K., Yoshioka T., Wakui Y. 2014, Vol.5 No.15Article ID:48588,8 pages DOI:10.4236/ijcm.2014.515120
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