Determination of toxicity of new benzilic acid derivatives


  • N. M. Tryschuk National University of Pharmacy, Ukraine
  • I. V. Kireyev National University of Pharmacy, Ukraine
  • S. V. Kolisnyk National University of Pharmacy, Ukraine
  • K. M. Sytnik National University of Pharmacy, Ukraine



acute toxicity, derivatives of benzilic acid, low-toxic compounds


The acute toxicity of 17 new derivatives of benzilic acid in outbred mice weighing 20-26 g has been determined. Animals were divided into 68 groups of 5 mice each. Each group of animals received the aqueous solution of the substance under study once orally by gavage in the doses of 100, 250, 750, 1000 mg/kg. The total duration of follow-up of the animals after administration of the test substance was 14 days. Administration of substances under the codes of KMS-10, KMS-19, KMS-49, KMS-68, KMS-70, KMS-71, KMS-73, KMS-228, KMS-230, KMS-284 in the dose of 1000 mg/kg caused no deaths of mice. It suggests that these substances are non-toxic in the selected doses. Since the dose of 1000 mg/kg did not result in the death of animals in these groups, the conclusion can be made that LD50>1000 mg/kg. According to the classification of K.K. Sidorov the substances under study can be referred to Class IV toxicity (low-toxic compounds).


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Experimental and Clinical Pharmacology