Determination of toxicity of new benzilic acid derivatives

Authors

  • N. M. Tryschuk National University of Pharmacy, Ukraine
  • I. V. Kireyev National University of Pharmacy, Ukraine
  • S. V. Kolisnyk National University of Pharmacy, Ukraine
  • K. M. Sytnik National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/nphj.16.2122

Keywords:

acute toxicity, derivatives of benzilic acid, low-toxic compounds

Abstract

The acute toxicity of 17 new derivatives of benzilic acid in outbred mice weighing 20-26 g has been determined. Animals were divided into 68 groups of 5 mice each. Each group of animals received the aqueous solution of the substance under study once orally by gavage in the doses of 100, 250, 750, 1000 mg/kg. The total duration of follow-up of the animals after administration of the test substance was 14 days. Administration of substances under the codes of KMS-10, KMS-19, KMS-49, KMS-68, KMS-70, KMS-71, KMS-73, KMS-228, KMS-230, KMS-284 in the dose of 1000 mg/kg caused no deaths of mice. It suggests that these substances are non-toxic in the selected doses. Since the dose of 1000 mg/kg did not result in the death of animals in these groups, the conclusion can be made that LD50>1000 mg/kg. According to the classification of K.K. Sidorov the substances under study can be referred to Class IV toxicity (low-toxic compounds).

References

Доклінічні дослідження лікарських засобів: Метод. рекоменд. / За ред. О.В.Стефанова. – К.: Авіценна, 2001. – 528 с.

Патерега І. П. // Наук.-техн. бюл. Інституту біології тварин і Державного науково-дослідного контрольного інституту ветпрепаратів та кормових добавок. – 2013. – Вип. 14, №3-4. – С. 189-192. – Режим доступу: http://nbuv.gov.ua/j-pdf/Ntbibt_2013_14_3-4_37.pdf

Саліонов В.О. // Актуальні питання фар мац. і мед. науки та практики. – 2015. – №3(19). – С. 19-24.

Сидоров К.К. Токсикология новых промышленных химических веществ. – М.: Медицина, 1973. – Вып. 3. – 47 с.

European convention for the protection of vertebrate animals used for experimental and other scientific purposes. – Council of Europe, Strasbourg, 1986. – 53 p.

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Published

2016-12-21

Issue

No. 4(88) (2016)

Section

Experimental and Clinical Pharmacology

License

Copyright (c) 2016 National University of Pharmacy

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