Some applications of physicochemical analysis in pharmacy

Authors

  • L. D. Grytsan National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/nphj.16.2125

Keywords:

physicochemical analysis, fusion diagram, boiling diagram, mutual solubility diagram of liquids, binary system

Abstract

After a brief review of the basic ideas and principles of the method of physicochemical analysis, its advantages and drawbacks, a number of its applications in pharmaceutical science and technology has been considered. The diagrams of fusion, boiling and liquid mutual solubility are of the most interest. When developing the technologies for manufacturing novel medicines the plotting and geometric analysis of phase diagrams for model binary systems allow to optimize the processes of crystallization, rectification, etc., in which phases are separated.

References

Аносов В.Я., Озерова М.И., Фиалков Ю.Я. Основы физико-химического анализа. – М.: Наука, 1976. – 503 с.

Беляев А.П., Кучук В.И., Евстратова К.И. и др. Физическая и коллоидная химия. – М.: ГЭОТАР-Медиа, 2010. – 704 с.

Валяшко В.М. Фазовые равновесия и свойства гидротермальных систем. – М.: Наука, 1990. – 270 с.

Горощенко Я.Г. Физизко-химический анализ гомогенных и гетерогенных систем. – К.: Наукова думка, 1978. – 490 с.

Кабачний В.І., Грицан Л.Д., Томаровська Т.О. та ін. Фізична та колоїдна хімія. – Х.: НФаУ ; Золоті сторінки, 2015. – 432 с.

Курнаков Н.С. Введение в физико-химический анализ. – М.-Л.: Изд-во АН СССР, 1940. – 564 с.

Ландау Л.Д., Лифшиц Е.М. Статистическая физика. Ч. 1. – М.: Наука, 1976. – 584 с.

Лебідь В.І., Грицан Л.Д. Фізико-хімічний аналіз / В кн.: Фармацевтична енциклопедія. II вид. – К.: Моріон, 2010. – С. 1481-1482.

Новосёлова А.В. Фазовые диаграммы, их построение и методы анализа. – М.: Изд-во Моск. ун-та, 1987. – 152 с.

Фиалков Ю.Я. Двойные жидкие системы. – К.: Техніка, 1969. – 220 с.

Фиалков Ю.Я. Физико-химический анализ жидких систем и растворов. – К.: Наукова думка, 1992. – 245 с.

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Published

2016-12-21

Issue

No. 4(88) (2016)

Section

Synthesis and Analysis of Biologically Active Substances

License

Copyright (c) 2016 National University of Pharmacy

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