The study of 2-((3-R-4-R1-4H-1,2,4-triazole-5-yl)thio) acetic acid salts as growth stimulators of winter wheat sprouts


  • R. O. Shcherbyna Zaporizhzhia State Medical University, Ukraine
  • D. M. Danilchenko Zaporizhzhia State Medical University, Ukraine
  • N. O. Khromykh Oles’ Honchar Dnipropetrovsk National University, Ukraine
  • Yu. V. Lykholat Oles’ Honchar Dnipropetrovsk National University, Ukraine



1, 2, 4-triazole, winter wheat sprouts, “Podolyanka” sort


Wheat is one of the most important and most widespread crop plants not only in Ukraine, but also in world agriculture in general. Wheat hybrids have many advantages, but seed production is a very complicated, high-tech and costly process. Derivatives of 1,2,4-triazol are interesting and promising in this respect.

Aim. To determine the effect of 2-((3-R-4-R1-4H-1,2,4-triazole-5-yl)thio) acetic acid salts on the growth quality indicators of winter wheat sprouting shoots (“Podolyanka” sort).

Materials and Methods. The objects of our research were 12 new water soluble 1,2,4-triazole derivatives.

Results and discussion. As the result of the study it was found that almost all salts of 2-((3-R-4-R1-4H-1,2,4-triazole-5-yl)thio) acetic acid were more or less able to affect the growth and development of winter wheat sprouts (“Podolyanka” sort). The intensity and severity of these effects are affected by substituents of the 1,2,4-triazole cycle at N3 and N4 atoms and cations associated with 2-((3-R-4-R1-4H-1,2,4-triazole-5-yl)thio) acetic acids. The promising compounds PKR-139, PKR-234, DKP-21 were found during our research. These substances almost exceeded the reference drug Auxin by all germination quality parameters. Interesting is the fact that the increase in the molecular weight of the substituent of the 1,2,4-triazole cycle at N4 atom in the molecules of 2-((4-R1-3-(morpholinomethylene)-4H-1,2,4-triazole-5-yl)thio) acetic acid ammonium salts results in the decrease of germination and the sprouting energy, but after that the germination rate slightly increases.

Conclusions. It has been found that compounds PKR-139, PKR-234, DKP-21 exhibit the most pronounced growth-stimulating activity.


Карамушка, О. М. Економічний розвиток підприємств зернового комплексу в умовах ризиків та глобалізації / О. М. Карамушка // Young Sci. – 2016. – Т. 32, № 5. – С. 61–64.

Шебанін, В. С. Зерновиробництву України – інноваційний розвиток / В. С. Шебанін // Вісник аграрної науки Причорномор’я. – 2014. – № 1. – С. 3–10.

TabHLH1, a bHLH–type transcription factor gene in wheat, improves plant tolerance to Pi and N deprivation via regulation of nutrient transporter gene transcription and ROS homeostasis / T. Yang, L. Hao, S. Yao et al. // Plant Physiol. and Biochem. – 2016. – Vol. 104. – P. 99–113. doi : 10.1016/j.plaphy.2016.03.023.

Comparison among four triazole fungicides on growth and development of sheath blight of rice pathogen Rhizoctonia solani Kühn AG1–1A / S. Datta, P. Dey, A. Sarkar et al. // Archives of Phytopathol. and Plant Protection. – 2016. – Vol. 49, Issue 9–10. – P. 1–13. doi : 10.1080/03235408.2016.1181945.

Synthesis and Antifungal Activity Evaluation of New 1,2,4–Triazole Derivatives Bearing Salicylidene Hydrazide Moiety / S. Demirayak,I.Kayagil, L. Yurttas, S. Er // Lett. in Drug Design & Discovery. – 2015. – Vol. 13, Issue 2. – P. 178–184. doi : 10.2174/1570180812666150723001545.

Exogenously applied plant growth regulators affect heat stressed rice pollens / S. Fahad, S. Hussain, S. Saud et al. // J. of Agronomy and Crop Sci. – 2016. – Vol. 202, Issue 2. – P. 139–150. doi : 10.1111/jac.12148.

Triazoles as plant growth regulators and stress protectants / R. A. Fletcher, A. Gilley, N. Sankhla, T. D. Davis // Horticultural Rev. – 2010. – Vol. 24. – P. 55–138. doi: 10.1002/9780470650776.ch3.

Дослідження рістстимулюючої активності похідних 1,2,4–триазолу на прикладі насіння соняшника простого / І. І. Аксьонова, Р. О. Щербина, О. І. Панасенко та ін. // Укр. біофармац. журн. – 2014. – № 6. – С. 78–82.

Пат. 110453 Україна, МПК (2016.01) A 61 K 31/00 C 07 D 249/00. Похідні 1,2,4–триазолів, що стимулюють ріст соняшника / Е. Г. Книш, О. І. Панасенко, А. А. Сафонов та ін. ; заявл. 05.04.2016 ; опубл. 10.10.2016, Бюл. № 19.

Mohamadi, N. Effect of Triamidefon fungicide on some growth parameters and antioxidant enzymes activity in tomato (Lycopersicom esculentum Mill.) plant under drought stress / N. Mohamadi, P. Rajaei // Int. J. Adv. Biol. Biom. Res. – 2013. – Vol. 1, Issue 4. – P. 341–350.

Reiss, A. Biological control of yellow rust of wheat (Puccinia striiformis) with Serenade® ASO (Bacillus subtilis strain QST713) / A. Reiss, L. N. Jørgensen // Crop. Protection. – 2017. – Vol. 93. – P. 1–8. doi : 10.1016/j.cropro.2016.11.009.

Robert, G. A. Triazole–induced drought stress amelioration on growth, yield, and pigments composition of Helianthus annuus L.(sunfl ower) / G. A. Robert, M. Rajasekar, P. Manivannan // Intern. Multidisciplinary Res. J. – 2016. – Vol. 5. – P. 6–15.

Насіння сільськогосподарських культур. Методи визначення якості. Розділ 2.2. «Методи аналізування схожості насіння і енергії проростання» : ДСТУ 4138–2002. – К. : Держспоживстандарт України, 2003.

Шишов, А. Д. Определение ростстимулирующих концентраций новых регуляторов роста и индукторов устойчивости растений / А. Д. Шишов, Г. Л. Матевосян // Фундаментальные исследования. – 2005. – № 9. – С. 46–47.






Experimental and Clinical Pharmacology