The effects of goutweed (Aegopodium podagraria L.) preparations on glycemia in intact rats and against the background of metformin
Keywords:Aegopodium podagraria L., glycemia, metformin, rats
The preparations obtained from goutweed (Aegopodium podagraria L.) are characterized by favorable metabolic effects, including the antidiabetic activity.
Aim. To determine the dose dependence of the effect of the extract and the tincture of goutweed on the glucose metabolism in intact rats, to evaluate the metabolic effects and the possibility of the combined use of the goutweed preparations with metformin.
Materials and methods. The experiments were conducted on intact rats. The influence of the extract and the tincture of goutweed (per se and combined with metformin) on the basal glycemia and the results of the glucose tolerance test were determined. The metabolic effects which are possibly interrelated (the changes in uric acid and electrolyte exchange) were also studied.
Results and discussion. The goutweed tincture exhibits the hypoglycemic action in intact rats after administration of single doses of 0.5; 1.0; 5.0 ml/kg, while the goutweed extract (100; 250; 500 mg/kg and 1.0 g/kg) does not demonstrate this action. The correlation analysis results indicate that certain interrelationship may exist between the effect of the extract on the electrolyte homeostasis and glucose metabolism (though these changes are moderate in intact animals), as well as between the effect of goutweed preparations on uric acid and the glucose exchange. The goutweed tincture in the doses of 0.5 and 1.0 ml/kg does not block the effects of metformin, and does not enhance its effect with the excessive decrease of the blood glucose concentration. The absence of a significant decrease of glycemia after combined administration of the tincture and low doses of metformin may reflect synergoantagonism (however, these phenomena were seen in intact animals, and the dose dependence of the metformin action did not change). In the glucose tolerance test the tincture in the dose of 1.0 ml/kg (but not 0.5 ml/kg) combined with metformin allows reducing its effective dose from 400 mg/kg to 200 mg/kg.
Conclusions. Goutweed tincture, in contrast to the extract, shows a dose-dependent hypoglycemic effect and is promising for combined use with metformin.
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