Comparison of chromatographic methods of analysis in a thin layer of the sorbent for identification of famotidine in tablets

Authors

  • A. V. Myhal National University of Pharmacy, Ukraine
  • M. Marksa Lithuanian University of Health Science, Lithuania
  • O. S. Golovchenko National University of Pharmacy, Ukraine
  • V. A. Georgiyants National University of Pharmacy, Ukraine
  • L. Ivanauskas Lithuanian University of Health Science, Lithuania

DOI:

https://doi.org/10.24959/nphj.17.2163

Keywords:

famotidine, identification, verification, thin layer chromatography

Abstract

Today three national manufacturers produce famotidine tablets, but the SPhU does not contain any monograph for this dosage form.

Aim. To verify TLC and study the possibility of using the HPTLC method for identification of famotidine in tablets.

Materials and methods. The objects of the study were three batches of famotidine tablets. TLC and HPTLC were used as the methods of the study.

Results and discussion. The possibility of using TLC and HPTLC methods for identification of famotidine tablets was confirmed in the study. The main spots of the test solutions corresponded to the size and the Rf value of the main spots of the standard solution. The Rf value for all solutions was 0.5.

Conclusions. Thus, TLC as well as HPTLC can be recommended for inclusion to the SPhU; however, HPTLC is more economically advantageous.

References

  1. 1. Derzhavnyi reiestr likarskykh zasobiv Ukrainy. Available at: http://www.drlz.com.ua/
  2. British Pharmacopoeia. Volume I & II, Medicinal and Pharmaceutical Substances, Famotidine, Р. 1–4. (2009). Her Majesty’s Stationery Office. London, 1, 1359 .
  3. European Pharmacopoeia 9.2. 8.0 04/2013:1012. (2017). Council of Europe. Strasbourg, 2211–2212.
  4. Famotidine tablets. (2017). United States Pharmacopoeia 39 – NF34. USP Convention Inc., 3852–3854.
  5. Novaković, J. (1999). High–performance thin–layer chromatography for the determination of ranitidine hydrochloride and famotidine in pharmaceuticals. Journal of Chromatography A, 846 (1–2), 193–198. doi: 10.1016/s0021–9673(99)00510–5
  6. Shah, D. A., Suthar, D. J., Nagda, C. D., Chhalotiya, U. K., Bhatt, K. K. (2014). Development and validation of hptlc method for estimation of ibuprofen and famotidine in pharmaceutical dosage form. Journal of Liquid Chromatography & Related Technologies, 37 (7), 941–950. doi: 10.1080/10826076.2013.765450
  7. 7. Derzhavna Farmakopeia Ukrainy, 3 (2(1)). (2015). Kharkiv: Ukrainskyi naukovui farmakopeinyi tsentr yakosti likarskykh zasobiv, 1128.
  8. Bezuglyi, P. O., Georgiiants, V. A., Grytsenko, I.S. (2013). Pharmatsevtychyi analiz. Kharkiv: NFAU; Zoloti storinky, 552.

Downloads

Published

2017-06-16

Issue

No. 2(90) (2017)

Section

Synthesis and Analysis of Biologically Active Substances

License

Copyright (c) 2017 National University of Pharmacy

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.