Comparison of chromatographic methods of analysis in a thin layer of the sorbent for identification of famotidine in tablets

Authors

  • A. V. Myhal National University of Pharmacy, Ukraine
  • M. Marksa Lithuanian University of Health Science, Lithuania
  • O. S. Golovchenko National University of Pharmacy, Ukraine
  • V. A. Georgiyants National University of Pharmacy, Ukraine
  • L. Ivanauskas Lithuanian University of Health Science, Lithuania

DOI:

https://doi.org/10.24959/nphj.17.2163

Keywords:

famotidine, identification, verification, thin layer chromatography

Abstract

Today three national manufacturers produce famotidine tablets, but the SPhU does not contain any monograph for this dosage form.

Aim. To verify TLC and study the possibility of using the HPTLC method for identification of famotidine in tablets.

Materials and methods. The objects of the study were three batches of famotidine tablets. TLC and HPTLC were used as the methods of the study.

Results and discussion. The possibility of using TLC and HPTLC methods for identification of famotidine tablets was confirmed in the study. The main spots of the test solutions corresponded to the size and the Rf value of the main spots of the standard solution. The Rf value for all solutions was 0.5.

Conclusions. Thus, TLC as well as HPTLC can be recommended for inclusion to the SPhU; however, HPTLC is more economically advantageous.

Author Biographies

A. V. Myhal, National University of Pharmacy

postgraduate student of the Pharmaceutical Chemistry Department

M. Marksa, Lithuanian University of Health Science

teaching assistant of the Analytical and Toxicological Chemistry Department

O. S. Golovchenko, National University of Pharmacy

Candidate of Pharmacy (Ph.D.), associate professor of the Pharmaceutical Chemistry Department

V. A. Georgiyants, National University of Pharmacy

Doctor of Pharmacy (Dr. habil.), professor, the head of the Pharmaceutical Chemistry Department

L. Ivanauskas, Lithuanian University of Health Science

Doctor of Biomedicine (Dr. habil.), “Pharmacy 08B” specialty, professor, the head of the Analytical and Toxicological Chemistry Department

References

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Shah, D. A., Suthar, D. J., Nagda, C. D., Chhalotiya, U. K., Bhatt, K. K. (2014). Development and validation of hptlc method for estimation of ibuprofen and famotidine in pharmaceutical dosage form. Journal of Liquid Chromatography & Related Technologies, 37 (7), 941–950. doi: 10.1080/10826076.2013.765450

7. Derzhavna Farmakopeia Ukrainy, 3 (2(1)). (2015). Kharkiv: Ukrainskyi naukovui farmakopeinyi tsentr yakosti likarskykh zasobiv, 1128.

Bezuglyi, P. O., Georgiiants, V. A., Grytsenko, I.S. (2013). Pharmatsevtychyi analiz. Kharkiv: NFAU; Zoloti storinky, 552.

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Published

2017-06-16

Issue

No. 2(90) (2017)

Section

Synthesis and Analysis of Biologically Active Substances

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