Development of the laboratory technology of the combined pessaries with acyclovir and essential oils
DOI:
https://doi.org/10.24959/nphj.17.2171Keywords:
genital herpes, pessaries, development, technology, acyclovir, essential oilsAbstract
The range of pessaries at the Ukrainian pharmaceutical market is represented by medicines containing substances of the synthetic origin for the treatment of genital herpes (GH). However, combined drugs with a wide range of pharmacological action and minimal side effects for treating GH are practically absent, except for rectal suppositories “Panavir” containing the purified extract from Solanum tuberosum stem. For this reason the question of expansion of the range of pessaries based on substances of the plant or synthetic origin is topical and important. Aim. To develop the laboratory technology of the combined pessaries with acyclovir and essential oils of tea tree and thyme. Materials and methods. The technological process for preparing pessaries was carried out in accordance to the generally accepted rules for preparing suppositories taking into account the nature and physicochemical properties of active pharmaceutical ingredients (API) and excipients. According to the methods of the State Pharmacopoeia of Ukraine (SPhU) the following parameters were determined on the samples of pessaries: description, uniformity, pH, melting point, time of complete deformation, disintegration time, and resistance. Quantitative determination of acyclovir was conducted by the method of absorption spectrophotometry in the UV spectrum at a wavelength of (265 ± 2) nm. The thermogravimetric studies were performed on a Q-1000 derivatograph of F. Paulik, I. Paulik, L. Efdei system. Results and discussion. Based on the biopharmaceutical and pharmacotechnological studies conducted the laboratory technology of the combined pessaries with acyclovir and essential oils of tea tree and thyme has been developed. The complex of experimental studies on selection of the amount of an emulsifier, fineness and the the choice of solvent for acyclovir, the choice of the rational technology for pessaries has been conducted. The technology proposed allows obtaining pessaries in accordance with the requirements of the SPhU. Conclusions. For the first time the laboratory technology of pessaries with acyclovir and essential oils of tea tree and thyme has been developed. The results obtained have shown the prospects for further study of the combined pessaries with acyclovir and essential oils of tea tree and thyme in order to introduce this dosage form into production.
References
Stephenson–Famy, A., Gardella, C. (2014). Herpes Simplex Virus Infection During Pregnancy. Obstetrics and Gynecology Clinics of
North America, 41(4), 601–614. doi: 10.1016/j.ogc.2014.08.006
Bardova, E. A. (2011). Medix Anti agins, 2, 44–52.
Lvov, N. D. (2012). Russkii meditcinskii zhurnal, 22, 1133–1137
Letiaeva, O. I., Ziganshin, O. R., Kudrevich, Yu.V., Gizinger, O. A. (2015). RMZh, 28, 1701–1704.
Levachkova, Yu. V., Lytvynova, O. M., Chernykh, V. V., Zaichenko, H. V., Sinitsyna, O. S., Chushenko, V. M. (2016). Patent of Ukraine
№ 107464. u201511570; declared 23.11.2015; published 10.06.2016, № 11, 6.
Derzhavne pidpryiemvstvo “Naukovo–ekspertnyi farmakopeinyi tsentr”. (2014). Supozytorii ta pesarii, vyhotovlenni v aptekakh. Derzhavna
Farmakopeia Ukrainy. (2-nd ed.). Kharkiv: RIREH, 716–723.
Derzhavne pidpryiemvstvo “Naukovo–ekspertnyi farmakopeinyi tsentr”. (2004). Derzhavna Farmakopeia Ukrainy. Dopov. 1. (1st ed.).
Kharkiv: RIREH, 520.
Levachkova, Yu. V., Yarnykh, T. G, Litvinova, A. M., Chushenko, V. M. (2016). Spectrophotometric determination of acyclovir in the
suppository. Der Pharma Chemica, 8 (2), 356–360.
Levachkova, Yu.V., Yarnykh, T. G, Litvinova, A. M. (2014). Antivirals today and the prospects of development in Ukraine. Ukrainskyi
biofarmatsevtychnyi zhurnal, 4, 18–22.
Tikhonov, O. I., Olmesekova, A. T., Mikhailenko, V. V. (2012). The termografic study of suppositories with the androgenic effect. Vìsnik
farmacìï, 1 (69), 30–32.
Yarnykh, T. H., Levachkova, Yu. V., Harkavtseva, O. A. (2011). Fitoterapiia. Chasopys, 1, 77–79.
Koch, C., Reichling, J., Schneele, J., Schnitzler, P. (2008). Inhibitory effect of essential oils against herpes simplex virus type 2. Phytomedicine,
(1–2), 71–78. doi: 10.1016/j.phymed.2007.09.003
MOZ of Ukraine. (2011). Farmatsevtychna rozrobka. Nastanova 42–3.0:2011. Kyiv, 33.
Downloads
Published
Issue
Section
License
Copyright (c) 2017 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
