The DDD-monitoring of consumption of fluoroquinolones when treating community-acquired pneumonia in a multi-specialty hospital in the Republic of Tajikistan
Keywords:pharmacoepidemiology, fluoroquinolones, community-acquired pneumonia
Community-acquired pneumonia is one of the most common diseases and is still the leading cause of death among infectious diseases. Such drugs as β-lactam antibiotics, new macrolides (azithromycin, clarithromycin) and respiratory fluoroquinolones are of the greatest importance in the treatment of community-acquired pneumonia in adult patients worldwide.
Aim. To analyze and assess the dynamics of consumption of fluoroquinolones for the treatment of community-acquired pneumonia in a multi-specialty hospital in the Republic of Tajikistan using the DDD-methodology.
Materials and methods. A retrospective descriptive analysis of medical prescriptions for pharmacotherapy of patients treated in the Pulmonology department of the Sogdigh Regional Clinical Hospital (Khujand, Republic of Tajikistan) was performed. The consumption of fluoroquinolones was estimated according to the ATC/DDD index of the WHO. The unit of measurement used was the number of grams of the active substance with further calculation of the DDD/100 bed-days and % of the total DDD.
Results and discussion. The DDD analysis of consumption of fluoroquinolones in the Pulmonology department of the multi-specialty hospital showed a significant change in the structure of consumption of this group of drugs for the initial antibiotic therapy of community-acquired pneumonia in the last five years. A clear tendency was observed to reduce the consumption of this class of drugs in 2011-2015. There is a significant reduction in the consumption of ofloxacin and levofloxacin against the background of a slight tendency to increase the demand for ciprofloxacin in the treatment of pneumonia in the inpatient drug treatment.
Conclusions. Monitoring of the consumption of antimicrobial drugs from the fluoroquinolone group for the treatment of community-acquired pneumonia in the Pulmonology department of the multi-specialty hospital using the ATS/DDD-methodology makes it possible to assess the tactics of community-acquired pneumonia treatment in this region, its compliance with the international standards and the risks of developing the drug-resistant microflora, in particular to fluoroquinolones.
Rozenbaum, M. H., Pechlivanoglou, P., Werf, T. S., Lo–Ten–Foe, J. R., Postma, M. J., Hak, E. (2012). The role of Streptococcus pneumoniae in community–acquired pneumonia among adults in Europe: a meta–analysis. European Journal of Clinical Microbiology & Infectious Diseases, 32 (3), 305–316. doi: 10.1007/s10096–012–1778–4
2. Agentstvo po statistike pri Prezidente Respubliki Tadzhikistan (2013).Dushanbe, 62.
Kaiumov, Kh. B. (2009). Osobennosti etiologicheskoi struktury bronkholegochnykh zabolevanii u naseleniia Resbubliki Tadzhikistan na sovremennom etape.Dushanbe, 115.
Oralbekova, Zh. M. (2013). Kliniko–morfologicheskie osobennosti i prediktory neblagopriiatnogo prognoza pri vnebolnichnoi pnevmonii, 25.
Baranov, A. A., Namazova–Baranova, L. S., Maianskii, N. A. (2013). Pediatricheskaia farmakologiia – Pediatric pharmacology, 5 (10), 6–12.
Chuchalin, A. G., Sinopalnikov, A. I., Kozlov, R. S. (2013). Infektcionnye bolezni: novosti, mneniia, obuchenie, 2 (3), 91–123.
ESAC Final Management Report 2009–2010 (2010). European Surveillance of Antimicrobial Consumption,153.
Chen, Y., Deng, W., Wang, S.–M., Mo, Q.–M., Jia, H., Wang, Q., Wang, X.–Y. (2011). Burden of Pneumonia and Meningitis Caused by Streptococcus pneumoniae in Chinaamong Children under 5 Years of Age: A Systematic Literature Review. PLoS ONE, 6 (11), e27333. doi: 10.1371/journal.pone.0027333
Bova, A. A. (2017). Voennaia meditcina, 2 (43), 98–109.
Sidorenko, S. V. (2011). Trudnyi patcient, 5 (9), 21–27.
Khamitov, R. F., Nikitina, R. B. (2011). Kazanskii meditcinskii zhurnal – Kazan medical journal, 1 (92), 1–4.
Albertson, T. E., Morrissey, B. M., Chan, A. L. (2012). Are Fluoroquinolones Superior Antibiotics for the Treatment of Community–Acquired Pneumonia? Current Infectious Disease Reports, 14 (3), 317–329. doi: 10.1007/s11908–012–0251–y
Léophonte, P. (2001). New generation fluoroquinolones and the treatment of adults with community–acquired pneumonia. Medecine et Maladies Infectieuses, 5 (31), 648–652.
Sinopalnikov, A. I. (2012). Spravochnik poliklinicheskogo vracha, 1, 47–53.
Sinopalnikov, A. I. (2016). Klinicheskaia meditcina, 11 (94), 851–860.
Sinopalnikov, A. I., Zaitcev, A. A. (2011). Spravochnik poliklinicheskogo vracha, 3, 16–21.
Blasi, F., Piffer, F., Zanardelli, M. et al. (2012). The role of fluoroquinolones in the treatment of patients hospitalised with community–acquired pneumonia. European Respiratory Disease, 1 (8), 61–65.
18. About ATC/DDD system. Available at: http://www. whocc.no/atc ddd
Shams, W. E., Evans, M. E. (2005). Guide to Selection of Fluoroquinolones in Patients with Lower Respiratory Tract Infections. Drugs, 65 (7), 949–991. doi: 10.2165/00003495–200565070–00004
Jones, M., Draghi, D., Thornsberry, C., Sahm, D. (2006). A current perspective on S.pneumoniae and H.influenzae resistance trends in Europe : GLOBAL Surveillance Study, 2005, 1629.
Bolieva, L. Z., Tcallagova, O. T., Gatagonova, T. M. (2014). Vladikavkazskii mediko–biologicheskii vestnik, 30 (20), 105–108.
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