The study of o/w emulsions using the rotating viscometer method and the method of spin probes

Authors

  • A. M. Lyapunova State Scientific Institution “Institute for Single Crystals” of the National Academy of Sciences of Ukraine, Ukraine
  • O. P. Bezugla State Scientific Institution “Institute for Single Crystals” of the National Academy of Sciences of Ukraine, Ukraine
  • O. M. Lyapunov State Scientific Institution “Institute for Single Crystals” of the National Academy of Sciences of Ukraine, Ukraine

DOI:

https://doi.org/10.24959/nphj.17.2190

Keywords:

emulsion, emulsifier, apparent viscosity, spine probe, EPR spectrum, rotational correlation time

Abstract

The study of o/w emulsions using the rotating viscometer method and the method of spin probes

The rheological properties of o/w emulsions used as vehicles for semi-solid preparations (SSP) depend on the composition of o/w and w/o emulsifiers to a large extent, and it is related to the structure of their aggregates in emulsions. In order to control the rheological parameters of emulsions it is necessary to know the regularities of the influence of the composition and properties of emulsifiers on these parameters, as well as the mechanism of emulsion stabilization, which depends on the structure of the aggregates formed by emulsifiers.

Aim. To study the relationship between the structure of the aggregates formed by emulsifiers and the rheological properties of o/w emulsions.

Materials and methods. The objects of the study were o/w emulsions stabilized with macrogol-40 stearate (M40S), glyceryl monostearate 40-55 (type II) (GMS) and cetostearyl alcohol (CSA). The rheological studies were performed by the rotational viscometer method. The structure of aggregates of emulsifiers was studied by the spin probes method. Probes simulating o/w and w/o emulsifiers with different localization of the radical were used.

Results and discussion. The apparent viscosity of emulsions stabilized with the o/w emulsifier (M40S) and a mixture of w/o emulsifiers (GMS and CSA) is maximal at a certain ratio between o/w and w/o emulsifiers. The increase in the rheological parameters correlates with the increase in the packing density of emulsifier molecules in the polar part of their aggregates; it in this case practically does not change at the level of the 5 and 16 carbon atoms of alkyl chains. This indicates formation of non-spherical aggregates which form a coagulation structure in the emulsion.

Conclusions. The change in the ratio between o/w and w/o emulsifiers results in the change in the structure of their aggregates, and it affects the rheological properties of o/w emulsions. Based on the results of the studies it is possible to reasonably control the rheological parameters of preparations with emulsions as a vehicle.

Author Biographies

A. M. Lyapunova, State Scientific Institution “Institute for Single Crystals” of the National Academy of Sciences of Ukraine

junior researcher of the Laboratory for Technology and Analysis of Medicinal Products

O. P. Bezugla, State Scientific Institution “Institute for Single Crystals” of the National Academy of Sciences of Ukraine

Candidate of Pharmacy (Ph. D.), senior researcher; head of the Laboratory for Technology and Analysis of Medicinal Products

O. M. Lyapunov, State Scientific Institution “Institute for Single Crystals” of the National Academy of Sciences of Ukraine

engineer of the 1st category of the Laboratory for Technology and Analysis of Medicinal Products

References

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Published

2017-12-04

Issue

No. 4(92) (2017)

Section

Technology of Medicines

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