The study of biopharmaceutical and adhesive characteristics of a dental gel
Keywords:periodontal diseases, dental gels, polymer gel base, mucosal adhesives, bioavailability, adhesion ability
Significant prevalence of dental pathologies among different age groups of the population of Ukraine dictates the need to find new effective medicines used in the treatment of oral cavity diseases. The choice of a dosage form and the optimal composition of the active pharmaceutical ingredients introduced in it to provide the necessary therapeutic effect is of importance in the treatment of periodontal diseases. For local treatment in dentistry gels are widely used; due to formation of aqueous internal structures they can include various chemotherapeutic substances in their composition, which makes it possible to obtain a dosage form with the multi-profile action. Considering the above, the research on developing the composition and technology of the dental gel with “Phytodent” tincture (PJSC “CPP Red Star”, Ukraine), choline salicylate 80 % (Basf Pharma, Switzerland) and lidocaine hydrochloride (Societa Italiana Medicinali Scandicci, Italy) has been conducted.
Aim. To select the optimal gel base from the solutions of polymers of the semi-synthetic and synthetic origin tested in different concentrations by studying the biopharmaceutical and adhesion characteristics of six samples of gels.
Materials and methods. The biopharmaceutical studies were performed by the method of direct diffusion in 2 % agar gel containing iron (III) chloride solution as an indicator. The degree of bioavailability of the amount of active substances from gels was determined by the diameter of the colored zone. The adhesive ability was studied using an electronic dynamometer.
Results and discussion. It has been found that addition of mucosal adhesives to a gel-former provides the prolonged action to gels and increases their adhesion ability.
Conclusions. The results of the biopharmaceutical studies have not been allowed determining the statistically reliable advantage of any of the gel samples. Based on the results of their adhesion ability the gel compositions with the best adhesion characteristics have been found; they can be recommended for further screening studies on creation of a new dental gel.
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