The study of stability of suppositories with the glifazin herbal complex during storage

Authors

  • A. S. Kutsanian National University of Pharmacy
  • N. A. Shram National University of Pharmacy
  • D. I. Dmitrievskiy National University of Pharmacy

DOI:

https://doi.org/10.24959/nphj.18.2195

Keywords:

suppositories, glifazin herbal complex, diabetes mellitus, stability

Abstract

The result of the search in the direction of creating an effective and save drug for the treatment of type 2 diabetes mellitus (DM) was development of suppositories with the glifazin herbal complex obtained from the herb of bean (Phaseolus vulgaris) and mung bean (Phaseolus aureus).

Aim. To study stability of suppositories with glifazin during storage.

Materials and methods. The study objects were rectal suppositories with the hypoglycemic activity containing the glifazin herbal complex in its composition and made on the hydrophilic polyethylene oxide base by the molding method. While storing suppositories their quality parameters (description, uniformity of mass, average weight, dissolution time, pH, microbiological purity, quantitative content of phenolic compounds) were determined using physical, physicochemical, pharmacotechnological and microbiological methods in accordance with the requirements of the State Pharmacopeia of Ukraine (SPhU).

Results and discussion. It has been experimentally proven that all quality parameters of the drug meet the requirements of the draft of the Quality Control Methods (QCM).

Conclusions. The results of the studies conducted have shown that suppositories are stable when stored in a dry, dark cool place for 2 years.

Author Biographies

A. S. Kutsanian, National University of Pharmacy

external PhD student of the Department of Industrial Technology of Drugs

N. A. Shram, National University of Pharmacy

Candidate of Pharmacy (Ph.D.), teaching assistant

D. I. Dmitrievskiy, National University of Pharmacy

Doctor of Pharmacy (Dr. habil.), professor of the Department of Industrial Technology of Drugs

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Published

2018-03-15

Issue

Section

Technology of Medicines