Development of the methods for the quantitative determination of fusidic acid and panthenol in the composition of “Fuzipam-derma” dermatological gel

Authors

  • P. P. Baiva National University of Pharmacy, Ukraine http://orcid.org/0000-0003-0408-0776
  • S. M. Kovalenko National University of Pharmacy, Ukraine
  • I. I. Baranova National University of Pharmacy, Ukraine
  • S. O. Mamedova National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/nphj.18.2197

Keywords:

acne, gel, chromatogram, panthenol, fusidic acid

Abstract

Aim. To develop and validate the methods for the quantitative determination of fusidic acid and panthenol in “Fuzipam-derma” gel.

Materials and methods. The determination was performed by high performance liquid chromatography (HPLC) according to the requirements of the State Pharmacopoeia of Ukraine (SPhU) 1.0 on a Prostar-210 liquid chromatograph, (Varian Chromatography System, USA).

Results and discussion. The methods for the quantitative determination of fusidic acid and panthenol in “Fuzipam-derma” gel have been developed. The appropriate chromatographic conditions have been chosen, due to them the peaks of fusidic acid and panthenol are completely separated from other gel components. The validation of the methods for the quantitative determination of fusidic acid and panthenol has been performed. The data obtained have shown that the methods are stable and reproducible in different days.

Conclusions. The methods for the quantitative determination of fusidic acid and panthenol in the composition of the new dermatological gel “Fuzipam-derma” for the treatment of grade І-ІІ acne has been developed using the HPLC method.

Author Biographies

P. P. Baiva, National University of Pharmacy

postgraduate student of the Department of Cosmetology and Aromology

S. M. Kovalenko, National University of Pharmacy

Doctor of Pharmacy (Dr.habil), рrofessor of the Department of Commodity Science

I. I. Baranova, National University of Pharmacy

д-р фарм. наук, професор, завідувачка кафедри товарознавства

S. O. Mamedova, National University of Pharmacy

канд. фарм. наук, асистент кафедри товарознавства

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Published

2018-03-15

Issue

Section

Synthesis and Analysis of Biologically Active Substances