The effect of the Ginger dry extract on the indicators of the carbohydrate metabolism under conditions of the experimental metabolic syndrome in Syrian golden hamsters

Authors

  • N. M. Kononenko National University of Pharmacy
  • V. V. Chikitkina National University of Pharmacy
  • M. V. Sorokyna National University of Pharmacy
  • M. O. Ostapets National University of Pharmacy

DOI:

https://doi.org/10.24959/nphj.18.2200

Keywords:

Ginger dry extract, metabolic syndrome, high-calorie diet, carbohydrate metabolism

Abstract

Aim. To study the effect of the ginger dry extract on the indicators of the carbohydrate metabolism in the experimental metabolic syndrome.

Materials and methods. The effect of the ginger dry extract on the carbohydrate metabolism was determined by the level of basal glycemia, basal insulinemia, HOMA-IR index, HbA1c level, the glycogen content in the liver and the body weight against the background of the metabolic syndrome induced by a high-calorie diet in Syrian golden hamsters.

Results and discussion. Consumption of high-calorie food for 6 weeks led to development of the metabolic syndrome, it was confirmed by an increase in the body weight, hyperglycemia, compensatory insulinemia, insulin resistance, increased glycogenolysis in the liver and glycosylation of proteins. The use of the ginger dry extract in the dose of 80 mg/kg over the period of 14 days reliably reduced blood glucose by 43.3 % and normalized insulinemia by 32.8 % affecting a decrease in the HOMA-IR index. The introduction of the ginger extract in the dose of 80 mg/kg was also accompanied by suppression of protein glycosylation by 29.6 % and restoration of glycogen-forming function of the liver. By its ability to restore the carbohydrate metabolism the ginger dry extract in the dose of 80 mg/kg did not differ from metformin and exceeded the effectiveness of the herbal drug “Arphasetin”. It is probably due to the powerful complex pharmacological action of phenolic compounds of ginger – gingerols and other components.

Conclusions. On the experimental model of the metabolic syndrome the use of the ginger dry extract normalized blood glucose, insulinemia, decreased insulin resistance and restored the glycogen content in the liver at the level of metformin. By the intensity of the pharmacological action the ginger extract exceeded the reference herbal drug “Arphasetin”. This fact is the basis for its further pharmacological study as a promising agent for the treatment of the metabolic syndrome and type 2 diabetes.

Author Biographies

N. M. Kononenko, National University of Pharmacy

Doctor of Medicine (Dr.habil), professor, head of the Department of Pathological Physiology

V. V. Chikitkina, National University of Pharmacy

Candidate of Biology (PhD), associate professor of the Department of Pathological Physiology

M. V. Sorokyna, National University of Pharmacy

postgraduate student of the Department of Pathological Physiology

M. O. Ostapets, National University of Pharmacy

Candidate of Medicine (PhD), teaching assistant of the Department of Pathological Physiology

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Published

2018-03-15

Issue

Section

Experimental and Clinical Pharmacology