Physicochemical studies of powders of plant extracts with the aim of creation of a soft dosage form for the treatment of dermatological diseases
Keywords:plant extracts, physicochemical properties, microscopic analysis, soft dosage form
In recent years, the problem of increasing the number of skin diseases has a steady tendency to increase. Therefore, the topical issue of modern pharmaceutical science is the creation of new effective herbal medicinal products for the treatment of dermatological diseases.
Aim. To study physicochemical characteristics of powders of dry plant extracts of Salvia officinalis leaves and Sophora flavescens root.
Materials and methods. The objects of the study were powders of dry plant extracts of Salvia officinalis leaves and Sophora flavescens root. The study of solubility and microscopy were carried out according to the methods of the State Pharmacopoeia of Ukraine.
Results and discussion. The powder of Salvia officinalis leaves is finely dispersed and practically insoluble in most solvents; the particle size ranges from 0.1 to 1.6 microns. The most uniform distribution of particles is observed in purified water, 96 % ethanol and PEO-400. The particle size of the extract of Sophora flavescens ranges from 0.1 to 0.8 microns. This makes it possible to refer it to dispersed powders. The extract of Sophora flavescens has the highest solubility in purified water and glycerin. The uniform distribution of particles is observed in most solvents.
Conclusions. The solubility of dry plant extracts has been determined. According to the results of microscopic studies the particle size has been found.
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