Physicochemical studies of powders of plant extracts with the aim of creation of a soft dosage form for the treatment of dermatological diseases

Authors

  • V. I. Hrytsenko National University of Pharmacy, Ukraine
  • L S Kienko National University of Pharmacy, Ukraine
  • Larysa Olexandrivna Bobrytska National University of Pharmacy, Ukraine http://orcid.org/0000-0002-4953-077X
  • M. M. Myga National University of Pharmacy, Ukraine

DOI:

https://doi.org/10.24959/nphj.19.1

Keywords:

plant extracts, physicochemical properties, microscopic analysis, soft dosage form

Abstract

In recent years, the problem of increasing the number of skin diseases has a steady tendency to increase. Therefore, the topical issue of modern pharmaceutical science is the creation of new effective herbal medicinal products for the treatment of dermatological diseases.

Aim. To study physicochemical characteristics of powders of dry plant extracts of Salvia officinalis leaves and Sophora flavescens root.

Materials and methods. The objects of the study were powders of dry plant extracts of Salvia officinalis leaves and Sophora flavescens root. The study of solubility and microscopy were carried out according to the methods of the State Pharmacopoeia of Ukraine.

Results and discussion. The powder of Salvia officinalis leaves is finely dispersed and practically insoluble in most solvents; the particle size ranges from 0.1 to 1.6 microns. The most uniform distribution of particles is observed in purified water, 96 % ethanol and PEO-400. The particle size of the extract of Sophora flavescens ranges from 0.1 to 0.8 microns. This makes it possible to refer it to dispersed powders. The extract of Sophora flavescens has the highest solubility in purified water and glycerin. The uniform distribution of particles is observed in most solvents.

Conclusions. The solubility of dry plant extracts has been determined. According to the results of microscopic studies the particle size has been found.

Author Biographies

V. I. Hrytsenko, National University of Pharmacy

Doctor of Pharmacy (Dr. habil), professor of the Department of Industrial Technology of Drugs

L S Kienko, National University of Pharmacy

postgraduate student of the Department of Industrial Technology of Drugs

Larysa Olexandrivna Bobrytska, National University of Pharmacy

Doctor of Pharmacy (Dr. habil), professor of the Department of Industrial Technology of Drugs

M. M. Myga, National University of Pharmacy

postgraduate student of the Department of Pharmacognosy

References

Potekaeva, N. N. (2011). Dermatologiya v klinicheskoy praktike. Moscow : Prakticheskaia meditsina, 208.

Bolotnaya, L. A. (2010). Ukrainskiy zhurnal dermatologii, venerologii, kosmetologii, 3 (38), 47–51.

Krvavych, A. S., Konechna, R. T., Pavliuk, I. V., Stadnytska, N. Ye., Novikov, V. P. (2013). Vcheni zapysky Tavriiskoho natsionalnoho universytetu im. V. I. Vernadskoho, 4, 276–280.

Dolya, V. S., Trzhetsinskiy, S. D., Mozul, V. I., Tretyak, N. I. (2013). Aktualni pytannia farmatsevtychnoi i medychoi nauky ta praktyky, 3 (13), 83–85.

Kosman, V. M., Pozharitskaia, O. N., Shikov, A. N., Makarov, V. G. (2012). Khimiia rastitelnogo syria, 1, 153–160.

Nizhenkovska, I.V., Tsurkan, O. O., Sedko, K. V. (2014). Fitoterapiia. Chasopys, 2, 58–61.

Olennikov, D. N., Tankhayeva, L. M., Pankrushina, N. A., Sandanov, D. V. (2012). Khimiia rastitelnogo syria, 4, 101–108.

Sandanov, D. V., Shobolova, A. B. (2011). Biulleten VSNTS SO RAMN, 1 (77), 268–270.

Vanden Berghe, W., De Naeyer, A., Dijsselbloem, N., David, J.–P., De Keukeleire, D., & Haegeman, G. (2011). Attenuation of ERK/RSK2–Driven NFκB Gene Expression and Cancer Cell Proliferation by Kurarinone, a Lavandulyl Flavanone Isolated from Sophora flavescens Ait. Roots. Endocrine, Metabolic & Immune Disorders Drug Targets, 11 (3), 247–261. https://doi.org/10.2174/187153011796429790

10. Derzhavna Farmakopeia Ukrainy. 2e vyd., 1. (2015). Kharkiv : Ukrainskyi naukovyi farmakopeinyi tsentr yakosti likarskykh zasobiv, 1128.

Published

2019-05-17

Issue

Section

Technology of Medicines