A comprehensive analysis of prescribing drugs for the treatment of cardiovascular diseases in a clinical setting


  • O. P. Balitska National Pirogov Memorial Medical University, Ukraine https://orcid.org/0000-0003-0990-7146
  • Yu. M. Grigoruk National Pirogov Memorial Medical University, Ukraine
  • O. D. Gaidai National Pirogov Memorial Medical University, Ukraine




cardiovascular diseases, state reimbursement, frequency ABC-analysis, VEN-analysis


Aim. To assess comprehensively the actual use of drugs for the treatment of the cardiovascular system, which cost is subject to the state reimbursement in a clinical setting.

Materials and methods. The list of medicines for the treatment of cardiovascular diseases, 100 medication administration records in a clinical setting, the National List of Essential Medicines, the Register of Medicines, which cost is subject to reimbursement, the State Formulary of Medicines were used in the study. The research methods were as follows: epidemiological, retrospective, statistical, expert assessments, as well as frequency, ABC-, VEN-analysis. A retrospective analysis was used for the analysis of case histories and outpatient cards. Using VEN-, ABC- and frequency analysis the distribution of drugs by certain categories and the degree of compliance of the actual clinical practice with the State Formulary of Ukraine and the Register of Medicines were determined; the drugs, which doctors preferred in the pharmacotherapy of cardiovascular diseases, were also analyzed. The epidemiological method was intended to assess the state of cardiovascular morbidity in Ukraine. The statistical analysis was used to process the results of the study.

Results and discussion. According to the questionnaire on the gender distribution of patients the percentage of women exceeded the percentage of men (females – 56 %, males – 44 %); the average age was 32 years old. The total cost of therapy was 34796.59 UAH, the average course of treatment was 9.5 days. The average cost of treatment for the average course was 347.96 UAH. It was found that the National List included only 15 % of the drugs prescribed. 71 % of the prescriptions corresponded to the category V – vital and essential medicines, 29 % belonged to the category N – non-essential medicines. According to the results of the ABC analysis, 17 drugs were included in the category A, 16 were in the category B, others in the category C.

Conclusions. The results obtained indicate maldistribution of funds in purchasing medicines for the treatment of cardiovascular diseases. A significant part of the drugs prescribed in the healthcare institution belongs to the high-cost ones. At the same time, there are no data on their proven effectiveness in the corresponding pathology of the cardiovascular system, and therefore, the feasibility of their prescription has not been substantiated.

Author Biographies

O. P. Balitska, National Pirogov Memorial Medical University

Candidate of Pharmacy (Ph.D.), associate professor of the Department of Pharmacy

Yu. M. Grigoruk, National Pirogov Memorial Medical University

Candidate of Pharmacy (Ph.D.), associate professor of the Department of Pharmacy

O. D. Gaidai, National Pirogov Memorial Medical University

senior lecturer of the Department of Pharmacy


Sait Derzhavnoi ustanovy “Ukrainskyi instytut stratehichnykh doslidzhen Ministerstva okhorony zdorov’ia Ukrainy”. (n.d.). Available at : http://www.uiph.kiev.ua/

Pro zatverdzhennia reiestru likarskykh zasobiv, vartist yakykh pidliahaie vidshkoduvanniu. (2017). Postanova Kabinetu Ministriv Ukrainy № 180 vid 16.03.2017. Available at : http://search.ligazakon.ua/l_doc2.nsf/link1/KP170180.html

“Natsionalnyi perelik osnovnykh likarskykh zasobiv”. (2009). Postanova Kabinetu Ministriv Ukrainy 25.03.2009 № 333. Available at : http://www.irf.ua/knowledgebase/publications/natsionalniy_perelik_osnovnikh_likarskikh_zasobiv/

Ziganshina, L. E., Niiazov, R. R., Polubentceva, E. I., Saitkulov, K. I. (2007). Metodicheskie rekomendatcii po provedeniiu ABC–, VEN– i chastotnogo analiza potrebleniia otdelnymi kategoriiami grazhdan lekarstvennykh sredstv pri pomoshchi informatcionnykh sistem. Moscow, 23.

Application of ABC-analysis in medical store of e.s.i.s Delhi. (n.d.). Available at : https://medind.nic.in/haa/t00/i1/haat00i.

ABC–analysis in hospitals of NCT of Delhi: Impact f drug policy. (n.d.). Available at : https://www.slideworld.org/viewslides.aspx/ABC-analysis-in-hospitals-of-NCTof-Delhi-Impact-of-drug-policy.ppt-144632.

An Application of ABC–Analysis in the Clothing Service at Centro Hospitalar Cova Da Beira (CHCB) – Portugal. (n.d.). Available at : https://papers.ssrn.com/sol3/pap.

Analysis of aggregate medicine use data. (n.d.). Available at : https://apps.who.int/medicinedocs/en/d/Js4882e/8.2.htm

Gupta, R., Gupta, K., Jain, B., & Garg, R. (2007). ABC– and VED–Analysis in Medical Stores Inventory Control. Medical Journal Armed Forces India, 63 (4), 325–327. https://doi.org/10.1016/s0377-1237(07)80006-2





Organization and Economy of Pharmacy