Development of a medicinal form with the essential oil of Thyme for the prophylaxis of gynecological diseases
DOI:
https://doi.org/10.24959/nphj.19.8Keywords:
vaginal diseases, essential oil of Thyme, pharmaceutical availability, antibacterial activityAbstract
Aim. To determine parameters of the pharmaceutical availability of the herbal medicine for the prophylaxis of gynecological diseases – egg-shaped vaginal suppositories with the essential oil of Thyme (the constants characterizing the kinetics of release and the half-release of thymol (T1/2)).
Materials and methods. The study object was egg-shaped vaginal suppositories with the essential oil of Thyme. Using the dialysis method through a semi-permeable membrane and the titrimetric method of analysis thymol was determined in a medicinal form in the in vitro experiments. The antibacterial properties and the bacteriostatic effect of the samples of the essential oil and egg-shaped vaginal suppositories with the essential oil of Thyme were studied using the laboratory methods of analysis.
Results and discussion. The qualitative therapy of inflammatory and bacterial gynecologic diseases in women has great medical and social importance. The use of medicinal plants and biologically active substances on their basis is one of the most widely spread methods for treating these pathologies. Representatives of Thymus L. (Thyme) genus of Lamiaceae L. family contain high concentrations of biologically active substances of phenolic, terpenes and flavonoid origin exhibiting a wide range of the pharmacological activity (anti-inflammatory, antibacterial, antioxidant, etc.) and possessing rather low toxicity.
Conclusions. The estimation of efficiency and quality of a new medical form of egg-shaped vaginal suppositories with the essential oil of Thyme is given. The parameters of pharmaceutical availability required when searching a new herbal medicine have been conducted. The optimal composition of the herbal medicine developed has been confirmed. The modern methods of research have been used. In the in vitro experiments the use of repeated research has allowed us to build the reliable graphs of the dependence of the concentration of thymol release from time. The high antibacterial and antimycotic effects of the essential oil and egg-shaped vaginal suppositories with the essential oil from Thyme have been determined in relation to strains of Candida pathogenic fungi, as well as bacilli and bacteria of St. aureus, St. pyogenes, B. anthracoides, E. coli, Kleb. pneumonium.
References
Levachkova, Iu. V., Litvinova, A. N., Iarnykh, T. G., Chushenko, V. N. (2015). Farmatciia Kazakhstana, 1, 40–44.
Litvinova, O. M., Levachkova, Y. V., & Chushenko, V. M. (2017). Development of the laboratory technology of the combined pessaries with acyclovir and essential oils. Vìsnik Farmacìï, 3 (91), 28–33. https://doi.org/10.24959/nphj.17.2171
Vasiukov, V. M. (2012). Izvestiia Samarskogo nauchnogo tcentra RAN, 14 (1), 64–68.
Levachkova, Yu. V., Yarnykh, T. H., Chushenko, V. M., Maloshtan, A. V. (2011). Klinichna farmatsiia, 1, 30–33.
Bykova, L. P., Sedelnikova, O. A., Kornacheva, Iu. V., Godovalov, A. P. (2011). Problemy meditcinskoi mikologii, 13 (2), 66–67.
Alekseeva, L. I., Teterniuk, L. V., Bystrushkin, A. G., Bulysheva, A. (2012). Rastitelnyi resursy, 1, 110–118.
Hroshovyi, T. A., Martseniuk, V. P., Kucherenko, L. I. (2008). Matematychne planuvannia eksperymentu pry provedenni naukovykh doslidzhen v farmatsii. Ternopil: Ukrmedknyha, 368.
Derzhavna Farmakopeya Ukrayini. Dopovnennya 3. (2009). Derzhavne pidpriyemstvo “Naukovo-ekspertnij farmakopejnij centr”. Kharkiv : Derzhavne pidpriyemstvo “Naukovo–ekspertnij farmakopejnij centr”, 279.
Machado, R. M., Palmeira–De–Oliveira, A., Martinez–De–Oliveira, J., & Palmeira–De–Oliveira, R. (2013). Vaginal Films for Drug Delivery. Journal of Pharmaceutical Sciences, 102 (7), 2069–2081. https://doi.org/10.1002/jps.23577
Fukleva, L. A., Puchkan, L. A. (2013). Seriia: Meditcina. Farmatciia, 18 (161), 207–210.
Maletska, Z. V., Davtian, L. L. (2013). Farmatsevtychnyi zhurnal, 3, 57–61.
Bezhenar, V. F., Drygin, A. N., Mikhailiukova, V. A., Erofeeva, L. N. (2013). Klinicheskaia bolnitca, 4 (06), 50–56.
Downloads
Published
Issue
Section
License
Copyright (c) 2019 National University of Pharmacy
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
