Determination of the quality indicators of “Argocid-mid”spray for veterinary use
Keywords:antiseptic spray, veterinary drug, silver citrate, copper citrate, dexpanthenol, quality indicators
Aim. To determine the quality indicators of “Argocid-mid” spray for veterinary use, which contains silver and copper citrates, dexpanthenol and is intended for the antiseptic treatment of cattle udder.
Materials and methods. The study object was spray samples containing silver and copper citrate, dexpanthenol and the composition of excipients. The quantitative content of silver ions was determined by the thiocyanometric method. The quantitative content of copper ions was determined by the method “Absorption spectrophotometry in the ultraviolet and visible regions”. The quantitative determination of dexpanthenol was conducted using liquid chromatography. Potentiometric determination of pH was carried out according to the methods of the State Pharmacopoeia of Ukraine (SPhU).
Results and discussion. According to the pharmacopoeial requirements, the following sections are included in the specification for a combined antimicrobial spray for veterinary medicine: “Description”, “Identification” (tests for dexpanthenol identification by HPLC, silver and copper by atomic absorption spectrometry and a specific reaction to citrates), “Relative density”, “pH”, “Packing contents”, “Packing tests”, “Microbiological purity”, “Quantitative determination”. In addition, analytical procedures include sections regulating the requirements to packaging, graphic design of packaging, storage conditions and shelf life.
Conclusions. As a result of the studies conducted the quality indicators of “Argocid-mid” spray for veterinary medicine have been determined according to the requirements of the general monograph of the SPhU 2: “Veterinary liquid medicinal products for cutaneous use” and “Liquid medicinal products for cutaneous use” in order to develop a registration dossier for a veterinary preparation. The studies will be used for the development of the spray with the antiseptic action and its implementation in production for use in veterinary medicine.
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